Notch4 - notch 4 Gene

Also Known as N4; Int3; Int-3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18132

Summary

Enables Notch binding activity. Involved in branching involved in blood vessel morphogenesis and negative regulation of endothelial cell differentiation. Acts upstream of or within several processes, including negative regulation of Notch signaling pathway; positive regulation of angiogenesis; and positive regulation of aorta morphogenesis. Located in cytoplasmic vesicle and endoplasmic reticulum. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system gland. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); dementia; ductal carcinoma in situ; schizophrenia; and systemic scleroderma. Orthologous to human NOTCH4 (Notch receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Notch4 Products (1)

mRNA	Protein	Name
NM_010929.2	NP_035059.2	neurogenic locus notch homolog protein 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Notch binding	IPI IPI: Inferred from physical interaction	24667410	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9111338	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	11344305	MGI
involved in morphogenesis of a branching structure	IMP IMP: Inferred from mutant phenotype	11344305	MGI
acts upstream of or within negative regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	24667410	MGI
involved in negative regulation of endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	11344305	MGI
acts upstream of or within positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	24667410	MGI
acts upstream of or within positive regulation of aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	18952909	MGI
acts upstream of or within regulation of Notch signaling pathway	IGI IGI: Inferred from genetic interaction	24667410	MGI
acts upstream of or within regulation of protein localization	IDA IDA: Inferred from direct assay	24667410	MGI
acts upstream of or within regulation of protein processing	IDA IDA: Inferred from direct assay	24667410	MGI
involved in vasculature development	IMP IMP: Inferred from mutant phenotype	11344305	MGI
acts upstream of or within venous blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	18952909	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	24667410	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	24667410	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
neurogenic locus notch homolog protein 4	Notch gene homolog 4

Notch4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Notch4	P31695	sel-10	Caenorhabditis elegans	Q93794	Anti Bait CoIP	9389650

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Notch4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P701028	Notch 4 Protein, Mouse (HEK293, His)	P31695 (E1042-L1441)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15670	BMS-906024	Inhibitor	99.91%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09452	NOTCH4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18097	Notch4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24571	Notch4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990177	Anti-Mouse Notch4 Antibody (HMN4-14)	Inhibitor	/	Unkown
HY-P992279	Anti-Notch4 Antibody		/	Unkown
HY-P990252	Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Notch4	NCBI	NCBI:4855