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Nppc - natriuretic peptide type C Gene

Also Known as CNP; lbab

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18159

Summary

This gene encodes a member of the natriuretic peptide family. Natriuretic peptides are involved in the control of blood pressure, extracellular fluid volume and electrolyte homeostasis. The encoded protein also plays a role in sensory neuron bifurcation, and is a critical regulator of endochondral bone growth. The encoded protein is a ligand for the natriuretic peptide receptor B, and is synthesized as a preprohormone which is cleaved to produce a mature peptide. Mutations in this gene are associated with dwarfism resulting from impaired endochondral ossification. [provided by RefSeq, Apr 2011]

Nppc Products (1)

mRNA	Protein	Name
NM_010933.5	NP_035063.1	C-type natriuretic peptide preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables signaling receptor binding	IDA IDA: Inferred from direct assay	14514678	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	30586761	MGI
acts upstream of or within animal organ development	IMP IMP: Inferred from mutant phenotype	17439653	MGI
involved in blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	30586761	MGI
involved in c-di-GMP signaling	IDA IDA: Inferred from direct assay	23127564	MGI
acts upstream of cGMP biosynthetic process	IMP IMP: Inferred from mutant phenotype	11259675	MGI
involved in cellular response to glycoprotein	IDA IDA: Inferred from direct assay	22987720	MGI
involved in chromosome organization	IMP IMP: Inferred from mutant phenotype	22696190	MGI
involved in cumulus cell differentiation	IMP IMP: Inferred from mutant phenotype	22696190	MGI
involved in gastric emptying	IDA IDA: Inferred from direct assay	23127564	MGI
involved in growth plate cartilage chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	11259675	MGI
involved in growth plate cartilage chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	11259675	MGI
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	28054671	MGI
acts upstream of meiotic cell cycle	IMP IMP: Inferred from mutant phenotype	20947764	MGI
involved in meiotic cell cycle process involved in oocyte maturation	IMP IMP: Inferred from mutant phenotype	22696190	MGI
involved in multicellular organismal locomotion	IMP IMP: Inferred from mutant phenotype	29501420	MGI
acts upstream of or within negative regulation of meiotic cell cycle	IMP IMP: Inferred from mutant phenotype	20947764	MGI
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	29501420	MGI
acts upstream of or within negative regulation of oocyte maturation	IMP IMP: Inferred from mutant phenotype	20947764	MGI
involved in oocyte development	IMP IMP: Inferred from mutant phenotype	22696190	MGI
involved in ovarian follicle development	IMP IMP: Inferred from mutant phenotype	22696190	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	17439653	MGI
acts upstream of or within regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	17439653	MGI
acts upstream of or within reproductive process	IMP IMP: Inferred from mutant phenotype	20947764	MGI
involved in response to axon injury	IMP IMP: Inferred from mutant phenotype	29501420	MGI
involved in response to decreased oxygen levels	IMP IMP: Inferred from mutant phenotype	29501420	MGI
involved in response to ischemia	IMP IMP: Inferred from mutant phenotype	30586761	MGI
involved in response to oxygen-glucose deprivation	IMP IMP: Inferred from mutant phenotype	29501420	MGI
involved in response to wounding	IMP IMP: Inferred from mutant phenotype	29501420	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
C-type natriuretic peptide	natriuretic peptide precursor C natriuretic peptide precursor type C

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09496	NPPC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20311	Nppc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26819	Nppc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nppc	NCBI	NCBI:4880