Ogg1 - 8-oxoguanine DNA-glycosylase 1 Gene

Also Known as Mmh

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18294

Summary

Enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity and microtubule binding activity. Acts upstream of or within base-excision repair. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; angiomyolipoma; carcinoma (multiple); eye disease (multiple); and reproductive organ Cancer (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase). [provided by Alliance of Genome Resources, Apr 2022]

Ogg1 Products (4)

mRNA Protein Name
NM_001410130.1 NP_001397059.1 N-glycosylase/DNA lyase isoform 3
NM_001410131.1 NP_001397060.1 N-glycosylase/DNA lyase isoform 4
NM_001410132.1 NP_001397061.1 N-glycosylase/DNA lyase isoform 5
NM_010957.5 NP_035087.3 N-glycosylase/DNA lyase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IMP
IMP: Inferred from mutant phenotype
12447686 MGI
enables microtubule binding IDA
IDA: Inferred from direct assay
15725623 MGI
enables oxidized purine nucleobase lesion DNA N-glycosylase activity IDA
IDA: Inferred from direct assay
9207108 MGI
enables oxidized purine nucleobase lesion DNA N-glycosylase activity IMP
IMP: Inferred from mutant phenotype
10557315 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA repair IGI
IGI: Inferred from genetic interaction
12447686 MGI
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
11532868 MGI
acts upstream of or within base-excision repair IDA
IDA: Inferred from direct assay
9207108 MGI
acts upstream of or within base-excision repair IMP
IMP: Inferred from mutant phenotype
10570187 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IMP
IMP: Inferred from mutant phenotype
11454679 MGI
located in nucleus IMP
IMP: Inferred from mutant phenotype
10557315 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

N-glycosylase/DNA lyase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147313 TH10785 Activator 99.93% Unkown
HY-112902 OGG1-IN-08 Inhibitor 99.18% Unkown
HY-139056 SU0268 Inhibitor 99.96% Unkown
HY-RS09763 OGG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179014 OGG1 activator-1 Activator / Unkown
HY-180404 SU0383 Inhibitor / Unkown
HY-RS16757 Ogg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23196 Ogg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ogg1 NCBI NCBI:4968