P4hb - prolyl 4-hydroxylase, beta polypeptide Gene

Also Known as PDI; Thbp; ERp59; Pdia1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18453

Summary

Enables Integrin binding activity. Acts upstream of or within cellular response to interleukin-7. Located in endoplasmic reticulum and external side of plasma membrane. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to human P4HB (prolyl 4-hydroxylase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

P4hb Products (1)

mRNA Protein Name
NM_011032.3 NP_035162.1 protein disulfide-isomerase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IPI
IPI: Inferred from physical interaction
21670307 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21670307 MGI
enables protein-disulfide reductase activity IMP
IMP: Inferred from mutant phenotype
31184304 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to interleukin-7 IDA
IDA: Inferred from direct assay
29581031 MGI
acts upstream of positive effect endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
31184304 MGI
involved in insulin processing IMP
IMP: Inferred from mutant phenotype
31184304 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
9493907 MGI
part of endoplasmic reticulum chaperone complex IDA
IDA: Inferred from direct assay
12475965 MGI
is active in endoplasmic reticulum lumen IMP
IMP: Inferred from mutant phenotype
31184304 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
21670307 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein disulfide-isomerase

  • ER protein 59

  • cellular thyroid hormone-binding protein

  • endoplasmic reticulum resident protein 59

  • p55

  • prolyl 4-hydroxylase subunit beta

Recombinant P4hb Proteins

Cat. No. Product Name Accession Purity
HY-P74658 P4HB Protein, Mouse (HEK293, His) P09103 (D20-L509) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09945 P4HB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18780 P4hb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-176936 Tau-aggregation-IN-5 Inhibitor / Unkown
HY-RS25269 P4hb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P4hb NCBI NCBI:5034