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Cat. No.: HY-176936

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Tau-aggregation-IN-5

Tau-aggregation-IN-5 is a Tau-aggregation inhibitor (EC₅₀ = 0.31 μM). Tau-aggregation-IN-5 targets P4HB covalently and activates mild ER stress. Tau-aggregation-IN-4 can be used for the study of neurodegenerative disorders such as Alzheimer’s and Pick’s diseases.

For research use only. We do not sell to patients.

CAS No.: 1283397-08-9
Formula: C₁₅H₁₃N₃O
Molecular Weight:251.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Tau-aggregation-IN-5 Chemical Structure

CAS No.: 1283397-08-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Tau-aggregation-IN-5 (Compound 2a) (0.008-10 μM,) dose-dependently clears tau accumulation in human induced pluripotent stem cell (hiPSC)-derived neurons, with an EC₅₀ of 190 nM and a maximum clearance rate exceeding 90%^[1].
Tau-aggregation-IN-5 (3 μM, 24 h) does not affect the level of non-aggregated tau protein in SH-SY5Y cells^[1].
Tau-aggregation-IN-5 (10 μM, 6 hours) results in significant changes in the expression of 590 genes in 22,537 transcripts in SH-SY5Y cells, including ERO1B, HSPA5, and HERPUD1^[1].
Tau-aggregation-IN-5 (10 μM, 2-6 h) significantly upregulates the ERAD-associated protein HERPUD1 in SH-SY5Y cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1283397-08-9
Molecular Weight 251.28
Formula C₁₅H₁₃N₃O
SMILES

O=C(C1=CNC2=C1C=CC(N)=C2)NC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Conway LP, et al. Discovery of a tau-aggregate clearing compound that covalently targets P4HB. Cell Chem Biol. 2025 Oct 16;32(10):1235-1248.e34. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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