Pde7a - phosphodiesterase 7A Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18583

About Pde7a

Chromosome 3: 19,277,272-19,365,486 reverse strand.GRCm39:CM000996.3

This gene has 10 transcripts (splice variants), 240 orthologues, 20 paralogues and is associated with 1 phenotype. Broad expression in CNS E11.5 (RPKM 11.8), whole brain E14.5 (RPKM 1.9) and 24 other tissues.

Summary

Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human PDE7A (phosphodiesterase 7A). [provided by Alliance of Genome Resources, Apr 2022]

Pde7a Products (4)

mRNA Protein Name
NM_001122759.2 NP_001116231.1 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform 2
NM_008802.3 NP_032828.2 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform 1 precursor
NM_001122759.2 NP_001116231.1 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform 2
NM_008802.3 NP_032828.2 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
11027622 MGI
Biological Process GO Annotation Evidence References Source
involved in cAMP-mediated signaling IDA
IDA: Inferred from direct assay
11027622 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pde7a Protein Structure

PDEase_I

PDEase_I: pfam00233 (210 - 443)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 482 a.a.
Protein Preferred Names Protein Names

high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-109586 BRL-50481 Inhibitor 99.81% Unkown
HY-170788 PDE7A-IN-1 Inhibitor 99.83% Unkown
HY-134937 BC8-15 Inhibitor / Unkown
HY-146201 PDE4B/7A-IN-1 99.63% Unkown
HY-146202 PDE4B/7A-IN-2 / Unkown
HY-179503 PDE/TRPA1/CHIT1-IN-1 Inhibitor / Unkown
HY-181762 Multitarget AD-IN-6 Inhibitor / Unkown
HY-RS10238 PDE7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10239 Pde7a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10240 Pde7a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W074537 P7-2104 Inhibitor 99.77% Unkown
HY-165553 ASB16165 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde7a NCBI NCBI:5150