Pfkl - phosphofructokinase, liver, B-type Gene

Also Known as PFK-B; PFK-L; ATP-PFK

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18641

Summary

Enables 6-phosphofructokinase activity. Acts upstream of or within several processes, including fructose 6-phosphate metabolic process; glycolytic process through fructose-6-phosphate; and negative regulation of Insulin secretion. Located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and sensory organ. Orthologous to human PFKL (phosphofructokinase, liver type). [provided by Alliance of Genome Resources, Apr 2022]

Pfkl Products (2)

mRNA Protein Name
NM_001358793.1 NP_001345722.1 ATP-dependent 6-phosphofructokinase, liver type isoform 2
NM_008826.5 NP_032852.2 ATP-dependent 6-phosphofructokinase, liver type isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 6-phosphofructokinase activity IDA
IDA: Inferred from direct assay
6450202 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within fructose 6-phosphate metabolic process IDA
IDA: Inferred from direct assay
8172601 MGI
acts upstream of or within glycolytic process through fructose-6-phosphate IDA
IDA: Inferred from direct assay
8172601 MGI
involved in glycolytic process through fructose-6-phosphate IDA
IDA: Inferred from direct assay
8172601 MGI
involved in glycolytic process through fructose-6-phosphate IMP
IMP: Inferred from mutant phenotype
35530161 MGI
acts upstream of or within negative regulation of insulin secretion IDA
IDA: Inferred from direct assay
9287040 MGI
acts upstream of or within response to glucose IDA
IDA: Inferred from direct assay
9287040 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
2521854 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-dependent 6-phosphofructokinase, liver type

  • 6-phosphofructokinase type B

  • 6-phosphofructokinase, liver type

  • phosphofructo-1-kinase isozyme B

  • phosphofructokinase 1

  • phosphohexokinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-182002 Apoptosis inducer 61 / Unkown
HY-RS10365 PFKL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18781 Pfkl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25270 Pfkl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pfkl NCBI NCBI:5211