Pip4k2a - phosphatidylinositol-5-phosphate 4-kinase, type II, alpha Gene

Also Known as Pip5k2a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18718

Summary

Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; and protein homodimerization activity. Involved in autophagosome-lysosome fusion; megakaryocyte development; and regulation of Autophagy. Located in lysosome. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and nose. Orthologous to human PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Pip4k2a Products (5)

mRNA Protein Name
NM_001355146.1 NP_001342075.1 phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 2
NM_001355147.1 NP_001342076.1 phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 3
NM_001355148.1 NP_001342077.1 phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 4
NM_001355149.1 NP_001342078.1 phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 5
NM_008845.4 NP_032871.3 phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26760201 MGI
Biological Process GO Annotation Evidence References Source
involved in autophagosome-lysosome fusion IMP
IMP: Inferred from mutant phenotype
29727621 MGI
involved in megakaryocyte development IMP
IMP: Inferred from mutant phenotype
16434494 MGI
involved in regulation of autophagy IMP
IMP: Inferred from mutant phenotype
29727621 MGI
Cellular Component GO Annotation Evidence References Source
located in lysosome IDA
IDA: Inferred from direct assay
29727621 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

  • 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha

  • PI(5)P 4-kinase type II alpha

  • PI5P4Kalpha

  • PIP4KII-alpha

  • diphosphoinositide kinase 2-alpha

  • phosphatidylinositol-4-phosphate 5-kinase, type II, alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139868 BAY-091 Inhibitor 98.45% Unkown
HY-136310 PIP4K-IN-a131 Inhibitor 99.42% Unkown
HY-183627 066ATZ Inhibitor / Unkown
HY-186111 BAY-297 Inhibitor / Unkown
HY-RS10562 PIP4K2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19282 Pip4k2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25772 Pip4k2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pip4k2a NCBI NCBI:5305