Pla2g4a - phospholipase A2, group IVA (cytosolic, calcium-dependent) Gene

Also Known as cPLA2; Pla2g4; cPLA2alpha; cPLA2-alpha

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18783

Summary

The protein encoded by this gene is a member of the Phospholipase A2 group IV family. This enzyme hydrolyzes membrane Phospholipids, thereby releasing the polyunsaturated fatty acid, arachidonic acid. Arachidonic acid is further metabolized into eicosanoids such as leukotrienes, thromboxanes and prostaglandins, that play important roles in regulating diverse biological processes such as inflammatory responses, membrane and actin dynamics, and tumorigenesis. A rise in intracellular calcium levels results in binding of calcium to the C2 domain of this protein, and triggers the translocation from the cytosol to intracellular membranes, including the Golgi apparatus. Disruption of this gene in mice led to decreased levels of eicosonaoids and platelet-activating factor, decreased allergic symptoms, and impaired reproductive ability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

Pla2g4a Products (2)

mRNA	Protein	Name
NM_001305632.1	NP_001292561.1	cytosolic phospholipase A2 isoform 2
NM_008869.4	NP_032895.1	cytosolic phospholipase A2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-dependent phospholipase A2 activity	IMP IMP: Inferred from mutant phenotype	9403693	MGI
enables phospholipase A2 activity	IDA IDA: Inferred from direct assay	10946309	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in arachidonate secretion	IDA IDA: Inferred from direct assay	10946309	MGI
acts upstream of or within arachidonate secretion	IMP IMP: Inferred from mutant phenotype	17293613	MGI
acts upstream of or within cellular response to antibiotic	IDA IDA: Inferred from direct assay	17293613	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	17293613	MGI
acts upstream of or within icosanoid biosynthetic process	IMP IMP: Inferred from mutant phenotype	17293613	MGI
involved in leukotriene biosynthetic process	IMP IMP: Inferred from mutant phenotype	9403693	MGI
involved in phosphatidylcholine catabolic process	IMP IMP: Inferred from mutant phenotype	9403693	MGI
involved in platelet activating factor biosynthetic process	IMP IMP: Inferred from mutant phenotype	9403692	MGI
involved in positive regulation of T-helper 1 type immune response	IMP IMP: Inferred from mutant phenotype	16172261	MGI
involved in positive regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	9403692	MGI
acts upstream of or within positive regulation of prostaglandin secretion	IMP IMP: Inferred from mutant phenotype	26828067	MGI
involved in prostaglandin biosynthetic process	IMP IMP: Inferred from mutant phenotype	9403692	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	10969066	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	17293613	MGI
located in cytosol	IDA IDA: Inferred from direct assay	10946309	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17293613	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cytosolic phospholipase A2	Cytosolic phospholipase A2 (CPLA2) Type IV PLA2 cytosolic PLA2 phospholipase A2 group IVA phospholipase A2, group 4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18540	KT109	Inhibitor	99.86%	Unkown
HY-RS10626	PLA2G4A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17434	Pla2g4a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23889	Pla2g4a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pla2g4a	NCBI	NCBI:5321