Prom1 - prominin 1 Gene

Also Known as Prom; AC133; CD133; Prom-1; Proml1; 4932416E19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19126

Summary

Predicted to enable actinin binding activity; Cadherin binding activity; and Cholesterol binding activity. Involved in camera-type eye photoreceptor cell differentiation and retina layer formation. Located in several cellular components, including brush border; photoreceptor outer segment; and prominosome. Is integral component of plasma membrane. Is expressed in several structures, including epithelium; eye; future hindbrain; genitourinary system; and nervous system. Used to study retinitis pigmentosa 41. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12 and retinitis pigmentosa 41. Orthologous to human PROM1 (prominin 1). [provided by Alliance of Genome Resources, Apr 2022]

Prom1 Products (8)

mRNA Protein Name
NM_001163577.1 NP_001157049.1 prominin-1 isoform s2 precursor
NM_001163578.1 NP_001157050.1 prominin-1 isoform s3 precursor
NM_001163581.1 NP_001157053.1 prominin-1 isoform s4 precursor
NM_001163582.1 NP_001157054.1 prominin-1 isoform s5 precursor
NM_001163583.1 NP_001157055.1 prominin-1 isoform s6 precursor
NM_001163584.1 NP_001157056.1 prominin-1 isoform s7 precursor
NM_001163585.1 NP_001157057.1 prominin-1 isoform s8 precursor
NM_008935.2 NP_032961.2 prominin-1 isoform s1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in camera-type eye photoreceptor cell differentiation IMP
IMP: Inferred from mutant phenotype
19228982 MGI
involved in retina layer formation IMP
IMP: Inferred from mutant phenotype
19228982 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16892058 MGI
located in brush border IDA
IDA: Inferred from direct assay
9356465 MGI
located in cell projection IDA
IDA: Inferred from direct assay
10587575 MGI
located in cilium IDA
IDA: Inferred from direct assay
17109118 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
15976444 MGI
located in microvillus IDA
IDA: Inferred from direct assay
9356465 MGI
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
19228982 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9356465 MGI
located in prominosome IDA
IDA: Inferred from direct assay
15976444 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
15316084 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prominin-1

  • antigen AC133 homolog

  • prominin-like 1

  • prominin-like protein 1

Prom1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86802 CD133 Antibody (YA6495) WB, IHC-P, IHC-F Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11198 PROM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17613 Prom1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24073 Prom1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991463 MS133 Inhibitor / Unkown
HY-P991431 Anti-CD133/PROM1 Antibody (CMab-43) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prom1 NCBI NCBI:8842