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Prox1 - prospero homeobox 1 Gene

Also Known as PROX-1; A230003G05Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19130

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; circulatory system development; and positive regulation of cell differentiation. Acts upstream of or within several processes, including animal organ development; epithelial cell differentiation; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and eye. Used to study dilated cardiomyopathy and obesity. Orthologous to human PROX1 (prospero homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Prox1 Products (2)

mRNA	Protein	Name
NM_001360827.1	NP_001347756.1	prospero homeobox protein 1
NM_008937.3	NP_032963.1	prospero homeobox protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16291864	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23723244	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23723244	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21040746	MGI

Biological Process GO Annotation	Evidence	Referencias	Source
acts upstream of or within acinar cell differentiation	IMP IMP: Inferred from mutant phenotype	22178591	MGI
involved in aorta smooth muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	19091769	MGI
involved in atrial cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	19091769	MGI
acts upstream of or within blood vessel endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	11927535	MGI
acts upstream of or within branching involved in pancreas morphogenesis	IMP IMP: Inferred from mutant phenotype	22178591	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12692551	MGI
involved in cerebellar granule cell differentiation	IMP IMP: Inferred from mutant phenotype	20808958	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	23723244	MGI
involved in dentate gyrus development	IMP IMP: Inferred from mutant phenotype	20808958	MGI
involved in embryonic retina morphogenesis in camera-type eye	IEP IEP: Inferred from expression pattern	12692551	MGI
involved in endocardium formation	IMP IMP: Inferred from mutant phenotype	19091769	MGI
acts upstream of or within epithelial cell migration	IMP IMP: Inferred from mutant phenotype	10888866	MGI
acts upstream of or within hepatocyte cell migration	IMP IMP: Inferred from mutant phenotype	10888866	MGI
involved in hepatocyte differentiation	IEP IEP: Inferred from expression pattern	15232737	MGI
acts upstream of or within hepatocyte proliferation	IMP IMP: Inferred from mutant phenotype	10888866	MGI
acts upstream of or within inner ear development	IMP IMP: Inferred from mutant phenotype	20186345	MGI
involved in lens fiber cell morphogenesis	IMP IMP: Inferred from mutant phenotype	10080188	MGI
involved in lens morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	10080188	MGI
involved in lens placode formation involved in camera-type eye formation	IEP IEP: Inferred from expression pattern	11850194	MGI
acts upstream of or within lymph vessel development	IMP IMP: Inferred from mutant phenotype	16170315	MGI
acts upstream of or within lymphatic endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	19056883	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	23723244	MGI
acts upstream of or within negative regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	12692551	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21040746	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	12692551	MGI
acts upstream of or within neuron fate determination	IMP IMP: Inferred from mutant phenotype	12692551	MGI
involved in neuronal stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	20808958	MGI
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	10080188	MGI
acts upstream of or within positive regulation of cell cycle checkpoint	IMP IMP: Inferred from mutant phenotype	21040746	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12692551	MGI
involved in positive regulation of forebrain neuron differentiation	IMP IMP: Inferred from mutant phenotype	20808958	MGI
involved in positive regulation of heart growth	IMP IMP: Inferred from mutant phenotype	19091769	MGI
involved in positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	20808958	MGI
involved in positive regulation of sarcomere organization	IMP IMP: Inferred from mutant phenotype	19091769	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16291864	MGI
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	10080188	MGI
involved in skeletal muscle thin filament assembly	IMP IMP: Inferred from mutant phenotype	19091769	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16291864	MGI
involved in venous blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	19091769	MGI
involved in ventricular cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	19091769	MGI
involved in ventricular cardiac myofibril assembly	IMP IMP: Inferred from mutant phenotype	19091769	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	19091769	MGI

Cellular Component GO Annotation	Evidence	Referencias	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11850194	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11850194	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
prospero homeobox protein 1	homeobox prospero-like protein PROX1 prospero-related homeobox 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS11203	PROX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-185120	ProX1-(SS)-DOTAGA_R		/	Unkown
HY-185120A	ProX1-(SS)-DOTAGA		/	Unkown
HY-RS19733	Prox1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20455	Nprl3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26229	Prox1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-P991202	Anti-TSHR Antibody (M22)		99.46%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prox1	NCBI	NCBI:5629