Klk6 - kallikrein related-peptidase 6 Gene

Also Known as BSP; MSP; Bssp; Klk29; Prss9; Prss18; neurosin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19144

Summary

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in positive regulation of G protein-coupled receptor signaling pathway and regulation of neuron projection development. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in secretory granule. Is expressed in several structures, including brain. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; demyelinating disease; and multiple system atrophy. Orthologous to human KLK6 (Kallikrein related peptidase 6). [provided by Alliance of Genome Resources, Apr 2022]

Klk6 Products (4)

mRNA Protein Name
NM_001164696.1 NP_001158168.1 kallikrein-6 precursor
NM_001164697.1 NP_001158169.1 kallikrein-6 precursor
NM_001164698.1 NP_001158170.1 kallikrein-6 precursor
NM_011177.2 NP_035307.2 kallikrein-6 precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kallikrein-6

  • brain serine protease

  • kallikrein 29

  • kallikrein 6

  • myelencephalon-specific protease

  • myofibril-bound protease

  • protease M

  • protease, serine, 18

  • protease, serine, 9

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124714 DKFZ-251 Inhibitor / Unkown
HY-124610 DKFZ-633 Inhibitor / Unkown
HY-182600 KLK6-IN-1 Inhibitor / Unkown
HY-RS07373 KLK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07384 KLK6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17290 Klk6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18037 Klk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23745 Klk6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Klk6 NCBI NCBI:5653