KLK6-IN-2
KLK6-IN-2 is a reversible non-covalent and selective KLK6 inhibitor, with an IC50 of 2.1 μM against hKLK6. KLK6-IN-2 acts as a reversible competitive inhibitor of boar Spermatozoa acrosin, with a Ki of 2.6 μM against porcine acrosin. KLK6-IN-2 exhibits trypanocidal activity against Trypanosoma brucei rhodesiense, with an IC50 of 3.71 μM.
For research use only. We do not sell to patients.
- CAS No.: 57323-76-9
- Formula: C14H14N2O
- Molecular Weight:226.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Description
IC50 & Target
[1]|
Trypanosoma |
KLK6 2.1 μM (IC50) |
In Vitro
KLK6-IN-2 (Compound 69) (range of concentrations; 15 min) acts as a reversible, competitive inhibitor of recombinant human KLK6 with an IC50 of 2.1 μM, a ligand efficiency of 0.43, and a Ki of 7.5 μM[1].
KLK6-IN-2 shows a favorable selectivity window for KLK6 over most tested kallikreins and trypsin-like serine proteases, with ~4- to ~9-fold selectivity relative to KLK5, KLK14, plasmin, and matriptase, but similar potency toward trypsin 3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 57323-76-9
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Molecular Weight 226.27
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Formula C14H14N2O
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SMILES
NC(C1=CC=C(COC2=CC=CC=C2)C=C1)=N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KLK6-IN-2 Related Classifications
HY-189095 Related Classifications
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