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Cat. No.: HY-189095

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KLK6-IN-2

KLK6-IN-2 is a reversible non-covalent and selective KLK6 inhibitor, with an IC₅₀ of 2.1 μM against hKLK6. KLK6-IN-2 acts as a reversible competitive inhibitor of boar Spermatozoa acrosin, with a K_i of 2.6 μM against porcine acrosin. KLK6-IN-2 exhibits trypanocidal activity against Trypanosoma brucei rhodesiense, with an IC₅₀ of 3.71 μM.

For research use only. We do not sell to patients.

CAS No.: 57323-76-9
Formula: C₁₄H₁₄N₂O
Molecular Weight:226.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KLK6-IN-2 Chemical Structure

CAS No.: 57323-76-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

Trypanosoma

KLK6

2.1 μM (IC₅₀)

All Parasite Isoforms :

All Kallikrein Isoforms :

In Vitro

KLK6-IN-2 (Compound 69) (range of concentrations; 15 min) acts as a reversible, competitive inhibitor of recombinant human KLK6 with an IC₅₀ of 2.1 μM, a ligand efficiency of 0.43, and a K_i of 7.5 μM^[1].
KLK6-IN-2 shows a favorable selectivity window for KLK6 over most tested kallikreins and trypsin-like serine proteases, with ~4- to ~9-fold selectivity relative to KLK5, KLK14, plasmin, and matriptase, but similar potency toward trypsin 3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 57323-76-9
Molecular Weight 226.27
Formula C₁₄H₁₄N₂O
SMILES

NC(C1=CC=C(COC2=CC=CC=C2)C=C1)=N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. de Freitas R , et al. Fragment-Based Discovery of KLK6 and KLK7 Inhibitors[J]. Journal of Chemical Information and Modeling, 2026.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols
Purity & Documentation
References

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KLK6-IN-2

All Parasite Isoforms

All Kallikrein Isoforms