Cyth3 - cytohesin 3 Gene

Also Known as CLM3; Grp1; ARNO3; Pscd3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19159

Summary

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity. Acts upstream of or within establishment of epithelial cell polarity and positive regulation of cell adhesion. Located in several cellular components, including adherens junction; bicellular tight junction; and ruffle. Is expressed in brain; neocortex; and telencephalon. Orthologous to human CYTH3 (cytohesin 3). [provided by Alliance of Genome Resources, Apr 2022]

Cyth3 Products (2)

mRNA Protein Name
NM_001163548.1 NP_001157020.1 cytohesin-3 isoform 2
NM_011182.4 NP_035312.3 cytohesin-3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
9072969 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10828067 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within establishment of epithelial cell polarity IMP
IMP: Inferred from mutant phenotype
20080746 MGI
acts upstream of or within positive regulation of cell adhesion IDA
IDA: Inferred from direct assay
10605025 MGI
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
20080746 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
20080746 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11445584 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10605025 MGI
located in ruffle IPI
IPI: Inferred from physical interaction
11445584 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytohesin-3

  • ARF nucleotide-binding site opener 3

  • PH, SEC7 and coiled-coil domain-containing protein 3

  • SEC7 homolog C

  • general receptor of phosphoinositides 1

  • mSec7-3

  • pleckstrin homology, Sec7 and coiled-coil domains 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03502 CYTH3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21544 Cyth3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28062 Cyth3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyth3 NCBI NCBI:9265