Ptafr - platelet-activating factor receptor Gene

Also Known as PAFR

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19204

About Ptafr

Chromosome 4: 132,291,378-132,309,994 forward strand.GRCm39:CM000997.3

This gene has 1 transcript (splice variant), 223 orthologues, 6 paralogues and is associated with 8 phenotypes. Broad expression in mammary gland adult (RPKM 12.2), subcutaneous fat pad adult (RPKM 7.6) and 16 other tissues.

Summary

This gene encodes a member of the G-protein coupled receptor 1 family of proteins. Binding of the encoded protein to its phospholipid ligand, platelet-activating factor (PAF), may regulate the inflammatory response and the perception of pain. Homozygous knockout mice for this gene exhibit impaired anaphylactic response, resistance to Bacterial infection, and reduced pain-related behavior. [provided by RefSeq, Aug 2015]

Ptafr Products (1)

mRNA Protein Name
NM_001081211.2 NP_001074680.1 platelet-activating factor receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables lipopolysaccharide binding IMP
IMP: Inferred from mutant phenotype
9013981 MGI
enables lipopolysaccharide immune receptor activity IMP
IMP: Inferred from mutant phenotype
9013981 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cytokine production IMP
IMP: Inferred from mutant phenotype
14742561 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
14742561 MGI
acts upstream of or within inositol trisphosphate biosynthetic process IMP
IMP: Inferred from mutant phenotype
9013981 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
9013981 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ptafr Protein Structure

7tmA_PAFR

7tmA_PAFR: cd15147 (15 - 302)

7tmA_PAFR

7tmA_PAFR: cd15147 (15 - 42)

7tmA_PAFR

7tmA_PAFR: cd15147 (51 - 76)

7tmA_PAFR

7tmA_PAFR: cd15147 (89 - 119)

7tmA_PAFR

7tmA_PAFR: cd15147 (131 - 153)

7tmA_PAFR

7tmA_PAFR: cd15147 (182 - 211)

7tmA_PAFR

7tmA_PAFR: cd15147 (224 - 254)

7tmA_PAFR

7tmA_PAFR: cd15147 (270 - 295)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
Protein Preferred Names Protein Names

platelet-activating factor receptor

  • PAF receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11347 PTAFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11348 Ptafr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11349 Ptafr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptafr NCBI NCBI:5724