Ptgs2 - prostaglandin-endoperoxide synthase 2 Gene

Also Known as COX2; Cox-2; PES-2; PHS-2; Pghs2; TIS10; PGHS-2; PHS II; gripghs

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19225

Summary

This gene encodes an enzyme that is a member of the prostaglandin G/H synthase family. The encoded protein converts arachidonic acid to prostaglandin endoperoxide H2 which is a key enzymatic step in prostaglandin biosynthesis. This gene is the inducible prostaglandin G/H synthase family member that is upregulated during inflammation. Aberrant regulation of this gene is associated with Cancer progression in several tissues and an increased risk of cardiovascular events. This gene is the target of many non-steroidal anti-inflammatory drugs. [provided by RefSeq, Sep 2015]

Ptgs2 Products (1)

mRNA Protein Name
NM_011198.5 NP_035328.2 prostaglandin G/H synthase 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heme binding IDA
IDA: Inferred from direct assay
12925531 MGI
enables prostaglandin-endoperoxide synthase activity IDA
IDA: Inferred from direct assay
1419907 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18650379 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
12925531 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anagen IMP
IMP: Inferred from mutant phenotype
15713628 MGI
involved in brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
20448152 MGI
acts upstream of or within cellular response to fluid shear stress IDA
IDA: Inferred from direct assay
24841674 MGI
involved in cellular response to non-ionic osmotic stress IMP
IMP: Inferred from mutant phenotype
21716255 MGI
acts upstream of or within cyclooxygenase pathway IDA
IDA: Inferred from direct assay
1419907 MGI
involved in cyclooxygenase pathway IDA
IDA: Inferred from direct assay
12925531 MGI
acts upstream of or within decidualization IMP
IMP: Inferred from mutant phenotype
10385625 MGI
acts upstream of or within embryo implantation IMP
IMP: Inferred from mutant phenotype
10385625 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21716255 MGI
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
21716255 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IMP
IMP: Inferred from mutant phenotype
21716255 MGI
involved in positive regulation of brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
20448152 MGI
involved in positive regulation of fever generation IDA
IDA: Inferred from direct assay
19940926 MGI
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
21716255 MGI
involved in positive regulation of prostaglandin biosynthetic process IMP
IMP: Inferred from mutant phenotype
21716255 MGI
involved in prostaglandin biosynthetic process IDA
IDA: Inferred from direct assay
12925531 MGI
acts upstream of or within prostaglandin secretion IMP
IMP: Inferred from mutant phenotype
32484881 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
12093889 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
8945508 MGI
involved in regulation of neuroinflammatory response IDA
IDA: Inferred from direct assay
29662056 MGI
acts upstream of or within response to nematode IDA
IDA: Inferred from direct assay
26644468 MGI
acts upstream of or within response to nematode IMP
IMP: Inferred from mutant phenotype
32484881 MGI
acts upstream of or within response to selenium ion IDA
IDA: Inferred from direct assay
26644468 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12021206 MGI
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
21716255 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
12355421 MGI
located in nuclear inner membrane IDA
IDA: Inferred from direct assay
9545330 MGI
located in nuclear outer membrane IDA
IDA: Inferred from direct assay
9545330 MGI
NOT located in nucleus IDA
IDA: Inferred from direct assay
12021206 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prostaglandin G/H synthase 2

  • PGH synthase 2

  • cyclooxygenase-2

  • glucocorticoid-regulated inflammatory cyclooxygenase

  • macrophage activation-associated marker protein P71/73

  • prostaglandin H2 synthase 2

Ptgs2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82796 Cyclooxygenase 2 Antibody (YA2541) WB, ICC/IF, IP Mouse
HY-P82796A Cyclooxygenase 2 Antibody (YA2541)(PBS only) WB, ICC/IF, IP Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163897 PROTAC NCOA4 degrader-1 Inhibitor 99.75% Unkown
HY-N6929 Angelic acid 99.20% Unkown
HY-RS11393 PTGS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121025 BUR1 Inhibitor 99.65% Unkown
HY-175813 NPSR1 antagonist-1 / Unkown
HY-N16797 Sanggenol C / Unkown
HY-N17632 Moracin G / Unkown
HY-N18209 4-Hydroxy-3-butylphthalide / Unkown
HY-N19877 Neokadsuranic acid B / Unkown
HY-N20647 Jioglutolide Inhibitor / Unkown
HY-RS16902 Ptgs2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23344 Ptgs2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptgs2 NCBI NCBI:5743