Ptp4a3 - protein tyrosine phosphatase 4a3 Gene

Also Known as Prl-3; pPtp4a3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19245

Summary

Predicted to enable protein tyrosine Phosphatase activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of vascular permeability; and regulation of vascular endothelial growth factor signaling pathway. Predicted to be located in endosome and plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; liver; metanephros; and retina layer. Orthologous to human PTP4A3 (protein tyrosine Phosphatase 4A3). [provided by Alliance of Genome Resources, Apr 2022]

Ptp4a3 Products (10)

mRNA Protein Name
NM_001166388.2 NP_001159860.1 protein tyrosine phosphatase type IVA 3 isoform 1
NM_001166389.2 NP_001159861.1 protein tyrosine phosphatase type IVA 3 isoform 1
NM_001166390.2 NP_001159862.1 protein tyrosine phosphatase type IVA 3 isoform 2
NM_001357591.2 NP_001344520.1 protein tyrosine phosphatase type IVA 3 isoform 1
NM_001411696.1 NP_001398625.1 protein tyrosine phosphatase type IVA 3 isoform 1
NM_001411697.1 NP_001398626.1 protein tyrosine phosphatase type IVA 3 isoform 1
NM_001411698.1 NP_001398627.1 protein tyrosine phosphatase type IVA 3 isoform 1
NM_001411699.1 NP_001398628.1 protein tyrosine phosphatase type IVA 3 isoform 1
NM_001411700.1 NP_001398629.1 protein tyrosine phosphatase type IVA 3 isoform 1
NM_008975.4 NP_033001.2 protein tyrosine phosphatase type IVA 3 isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
23117660 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within endothelial cell migration IMP
IMP: Inferred from mutant phenotype
24403062 MGI
acts upstream of or within positive regulation of vascular permeability IMP
IMP: Inferred from mutant phenotype
24403062 MGI
acts upstream of or within regulation of vascular endothelial growth factor signaling pathway IMP
IMP: Inferred from mutant phenotype
24403062 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein tyrosine phosphatase type IVA 3

  • protein-tyrosine phosphatase of regenerating liver 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135457 JMS-053 Inhibitor 98.0% Unkown
HY-183953 JMS-038 Inhibitor / Unkown
HY-RS11411 PTP4A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19807 Ptp4a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26303 Ptp4a3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptp4a3 NCBI NCBI:11156