Ptpn1 - protein tyrosine phosphatase, non-receptor type 1 Gene

Also Known as PTP1B; PTP-1B; PTP-HA2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19246

Summary

Predicted to enable several functions, including protein Phosphatase 2A binding activity; signaling receptor binding activity; and zinc ion binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; negative regulation of signal transduction; and peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity. Acts upstream of or within Insulin Receptor signaling pathway and protein dephosphorylation. Located in early endosome and sorting endosome. Is expressed in central nervous system; midbrain; and superior colliculus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine Phosphatase non-receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn1 Products (1)

mRNA	Protein	Name
NM_011201.3	NP_035331.3	tyrosine-protein phosphatase non-receptor type 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	15632081	MGI
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	17068137	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in IRE1-mediated unfolded protein response	IMP IMP: Inferred from mutant phenotype	15465829	MGI
involved in insulin receptor recycling	IMP IMP: Inferred from mutant phenotype	17068137	MGI
acts upstream of or within insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15632081	MGI
involved in negative regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	23639442	MGI
involved in negative regulation of PERK-mediated unfolded protein response	IMP IMP: Inferred from mutant phenotype	21216966	MGI
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21216966	MGI
involved in negative regulation of vascular endothelial growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	23639442	MGI
involved in peptidyl-tyrosine dephosphorylation	IMP IMP: Inferred from mutant phenotype	14966296	MGI
involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IGI IGI: Inferred from genetic interaction	23639442	MGI
involved in platelet-derived growth factor receptor-beta signaling pathway	IMP IMP: Inferred from mutant phenotype	14966296	MGI
acts upstream of positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	15465829	MGI
acts upstream of or within protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	15632081	MGI
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	15465829	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21216966	MGI
located in early endosome	IDA IDA: Inferred from direct assay	23639442	MGI
is active in endosome lumen	IDA IDA: Inferred from direct assay	23639442	MGI
located in sorting endosome	IDA IDA: Inferred from direct assay	23639442	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tyrosine-protein phosphatase non-receptor type 1	protein-protein-tyrosine phosphatase HA2 protein-tyrosine phosphatase 1B protein-tyrosine phosphatase HA2

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145923	Osunprotafib	Inhibitor	99.43%	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153446	Tegeprotafib	Inhibitor	99.30%	Unkown
HY-RS11415	PTPN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-145923B	Osunprotafib hydrochloride	Inhibitor	/	Unkown
HY-156606	Anticancer agent 142	Inhibitor	/	Unkown
HY-178716	PTPN2/1-IN-4		/	Unkown
HY-183937A	PD-305		/	Unkown
HY-N19872	Mukurozioside IIb		/	Unkown
HY-N19873	Mukurozioside IIa		/	Unkown
HY-P11604	C16 acid-I-{Lys(C10 diacid)}-KQELRRIGDEF	Inhibitor	/	Unkown
HY-RS17205	Ptpn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23657	Ptpn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptpn1	NCBI	NCBI:5770