PTPN1 - protein tyrosine phosphatase non-receptor type 1 Gene

Also Known as PTP1B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5770

About PTPN1

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:50,510,383-50,585,241 (from NCBI)

This gene has 2 transcripts (splice variants), 209 orthologues, 35 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 30.4), appendix (RPKM 29.5) and 25 other tissues.

Summary

The protein encoded by this gene is the founding member of the protein tyrosine Phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of Insulin signaling by dephosphorylating the phosphotryosine residues of Insulin Receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and Tyk2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

PTPN1 Products (2)

mRNA	Protein	Name
NM_001278618.2	NP_001265547.1	tyrosine-protein phosphatase non-receptor type 1 isoform 2
NM_002827.4	NP_002818.1	tyrosine-protein phosphatase non-receptor type 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	22169477	GOA
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	21135139	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8702689	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	22169477	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	18074158	GOA
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	18819921	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	18074158	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21135139	GOA
involved in endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	22169477	GOA
involved in negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	22045810	GOA
involved in negative regulation of PERK-mediated unfolded protein response	IDA IDA: Inferred from direct assay	21216966	GOA
involved in peptidyl-tyrosine dephosphorylation	IDA IDA: Inferred from direct assay	21135139	GOA
involved in peptidyl-tyrosine dephosphorylation	IMP IMP: Inferred from mutant phenotype	14966296	GOA
involved in platelet-derived growth factor receptor-beta signaling pathway	IMP IMP: Inferred from mutant phenotype	14966296	GOA
involved in positive regulation of protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	21216966	GOA
involved in positive regulation of receptor catabolic process	IMP IMP: Inferred from mutant phenotype	22045810	GOA
involved in protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	22045810	GOA
involved in regulation of endocytosis	IDA IDA: Inferred from direct assay	21135139	GOA
involved in regulation of hepatocyte growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18819921	GOA
involved in regulation of intracellular protein transport	IMP IMP: Inferred from mutant phenotype	22045810	GOA
involved in regulation of signal transduction	IMP IMP: Inferred from mutant phenotype	21135139	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic side of endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	1739967	GOA
located in early endosome	IDA IDA: Inferred from direct assay	21135139	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	21135139	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	28246125	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN1 Protein Structure

Y_phosphatase

0
100
200
300
400
435 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein phosphatase non-receptor type 1	protein tyrosine phosphatase, placental

PTPN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTPN1	P18031	NTRK1	Homo sapiens	P04629	Filter Binding	12237455
Intra	PTPN1	P18031	TMEM41A	Homo sapiens	Q96HV5	Validated Y2H	32296183
Intra	PTPN1	P18031	TMEM41A	Homo sapiens	Q96HV5	Y2H Prey Pooling	32296183
Intra	PTPN1	P18031	TMEM41A	Homo sapiens	Q96HV5	Y2H Array	32296183
Intra	PTPN1	P18031	LAT	Homo sapiens	O43561	Cosedimentation	12857726
Intra	PTPN1	P18031	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	PTPN1	P18031	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	PTPN1	P18031	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	PTPN1	P18031	CAPN1	Homo sapiens	P07384	Protease Assay	9407132
Cross	PTPN1	P18031	Pdgfrb	Mus musculus	P05622	Anti Tag CoIP	12614164
Cross	PTPN1	P18031	Pdgfrb	Mus musculus	P05622	Pull Down	18515860
Intra	PTPN1	P18031	INSR	Homo sapiens	P06213-1	X-Ray Diffraction	16271887
Intra	PTPN1	P18031	PIGP	Homo sapiens	P57054	Y2H Prey Pooling	32296183
Intra	PTPN1	P18031	PIGP	Homo sapiens	P57054	Validated Y2H	32296183
Intra	PTPN1	P18031	PIGP	Homo sapiens	P57054	Y2H Array	32296183
Intra	PTPN1	P18031	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	PTPN1	P18031	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	PTPN1	P18031	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	PTPN1	P18031	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	PTPN1	P18031	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	PTPN1	P18031	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	PTPN1	P18031	GHR	Homo sapiens	P10912	Array	12907755
Intra	PTPN1	P18031	GHR	Homo sapiens	P10912	Phosphatase Assay	12907755
Intra	PTPN1	P18031	EGFR	Homo sapiens	P00533	Anti Tag CoIP	24658140
Intra	PTPN1	P18031	EGFR	Homo sapiens	P00533	IF	9050838
Intra	PTPN1	P18031	EGFR	Homo sapiens	P00533	Anti Tag CoIP	9050838
Intra	PTPN1	P18031	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	PTPN1	P18031	CTTN	Homo sapiens	Q14247	Pull Down	18387954
Intra	PTPN1	P18031	NTRK3	Homo sapiens	Q16288	Filter Binding	12237455
Cross	PTPN1	P18031	Cdh2	Mus musculus	P15116	Anti Bait CoIP	11106648
Intra	PTPN1	P18031	GRB2	Homo sapiens	P62993	CoIP	10660596
Intra	PTPN1	P18031	INSR	Homo sapiens	P06213	CoIP	11579209
Intra	PTPN1	P18031	INSR	Homo sapiens	P06213	Protein Kinase Assay	11506178
Intra	PTPN1	P18031	INSR	Homo sapiens	P06213	Phosphatase Assay	12237455
Intra	PTPN1	P18031	INSR	Homo sapiens	P06213	Phosphatase Assay	11579209
Intra	PTPN1	P18031	INSR	Homo sapiens	P06213	Filter Binding	12237455
Intra	PTPN1	P18031	IGF1R	Homo sapiens	P08069	BRET	16926280
Intra	PTPN1	P18031	IGF1R	Homo sapiens	P08069	CoIP	8999839
Intra	PTPN1	P18031	JAK2	Homo sapiens	O60674	CoIP	11694501
Intra	PTPN1	P18031	JAK2	Homo sapiens	O60674	Phosphatase Assay	15821101
Intra	PTPN1	P18031	JAK2	Homo sapiens	O60674	Pull Down	11970898
Intra	PTPN1	P18031	JAK2	Homo sapiens	O60674	Phosphatase Assay	11970898
Intra	PTPN1	P18031	STAT3	Homo sapiens	P40763	Phosphatase Assay	11970898
Intra	PTPN1	P18031	TXN	Homo sapiens	P10599	Anti Tag CoIP	24976139
Intra	PTPN1	P18031	CAV1	Homo sapiens	Q03135	Anti Tag CoIP	16388599
Intra	PTPN1	P18031	CAV1	Homo sapiens	Q03135	Phosphatase Assay	16388599
Intra	PTPN1	P18031	EPOR	Homo sapiens	P19235	Pull Down	14527337
Intra	PTPN1	P18031	SRC	Homo sapiens	P12931	Anti Bait CoIP	16115959
Intra	PTPN1	P18031	SRC	Homo sapiens	P12931	CoIP	15866871
Intra	PTPN1	P18031	SRC	Homo sapiens	P12931	Protein Kinase Assay	9600099
Intra	PTPN1	P18031	SRC	Homo sapiens	P12931	BiFC	17092689
Intra	PTPN1	P18031	SRC	Homo sapiens	P12931	Anti Tag CoIP	16115959
Intra	PTPN1	P18031	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Prey Pooling	32296183
Intra	PTPN1	P18031	TIMMDC1	Homo sapiens	Q9NPL8	Validated Y2H	32296183
Intra	PTPN1	P18031	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Array	32296183
Intra	PTPN1	P18031	BCAR1	Homo sapiens	P56945	CoIP	15866871
Intra	PTPN1	P18031	ITGB3	Homo sapiens	P05106	Anti Tag CoIP	16115959
Intra	PTPN1	P18031	TRPV6	Homo sapiens	Q9H1D0	Anti Tag CoIP	15894168
Intra	PTPN1	P18031	TRPV6	Homo sapiens	Q9H1D0	Phosphatase Assay	17197020
Intra	PTPN1	P18031	TRPV6	Homo sapiens	Q9H1D0	Phosphatase Assay	15894168
Intra	PTPN1	P18031	STAT5A	Homo sapiens	P42229	Phosphatase Assay	12237455
Intra	PTPN1	P18031	STAT5A	Homo sapiens	P42229	Filter Binding	12237455
Cross	PTPN1	P18031	Bcar1	Mus musculus	Q61140	Anti Tag CoIP	12023880
Cross	PTPN1	P18031	Bcar1	Mus musculus	Q61140	Phosphatase Assay	16644720
Cross	PTPN1	P18031	Sumo1	Mus musculus	P63166	Anti Tag CoIP	17159996
Intra	PTPN1	P18031	BCR	Homo sapiens	P11274-1	Pull Down	9566916
Intra	PTPN1	P18031	BCR	Homo sapiens	P11274-1	Anti Tag CoIP	9566916
Cross	PTPN1	P18031	Bcar1	Rattus norvegicus	Q63767	Anti Tag CoIP	8940134
Cross	PTPN1	P18031	Bcar1	Rattus norvegicus	Q63767	Anti Bait CoIP	8940134
Cross	PTPN1	P18031	Bcar1	Rattus norvegicus	Q63767	Pull Down	8940134
Cross	PTPN1	P18031	Grb2	Rattus norvegicus	P62994	Pull Down	8940134
Cross	PTPN1	P18031	Irs1	Rattus norvegicus	P35570	CoIP	10660596
Cross	PTPN1	P18031	Irs1	Rattus norvegicus	P35570	Phosphatase Assay	10660596
Cross	PTPN1	P18031	Plcg1	Rattus norvegicus	P10686	Pull Down	17128263
Cross	PTPN1	P18031	Src	Rattus norvegicus	Q9WUD9	Pull Down	31585087
Cross	PTPN1	P18031	Crk	Rattus norvegicus	Q63768	Pull Down	8940134

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73685	PTP1B Protein, Human (His)	P18031 (E2-N321)	≥ 95%, as determined by reducing SDS-PAGE.

PTPN1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81300	Phospho-PTP1B (Ser352) Antibody (YA1027)	WB, ICC/IF, IP	Human
HY-P81300A	Phospho-PTP1B (Ser378) Antibody (YA1028)	WB, IHC-P	Human
HY-P81300AA	Phospho-PTP1B (Ser378) Antibody (YA1028)(PBS only)	WB, IHC-P	Human
HY-P82031	PTP1B Antibody (YA1776)	WB, IHC-F, IHC-P, ICC/IF	Human
HY-P82031A	PTP1B Antibody (YA1776)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human
HY-P84143	PTP1B Antibody (YA3840)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84143A	PTP1B Antibody (YA3840)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Bubonic Plague	Black Death Plague, Bubonic Plague, Septicemic Pestis Bubonica
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Leptin Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Diabetes Mellitus	Diabetes
Hepatic Adenomas, Familial	Hepatic Adenoma, Somatic Familial Hepatic Adenoma Familial Liver Cell Adenomas Liver Cell Adenomas, Familial Hepatic Adenomas Familial HEPAF Ha Hepatocellular Adenomas Hepatocellular Adenoma
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Rett Syndrome	Atypical Rett Syndrome RTT Rett Disorder Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Preserved Speech Variant Rett Syndrome, Atypical Rett'S Disorder Rett Syndrome Variant Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Cerebroatrophic Hyperammonemia Rett Like Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Noonan Syndrome With Multiple Lentigines	Leopard Syndrome Multiple Lentigines Syndrome Moynahan Syndrome Cardiomyopathic Lentiginosis Progressive Cardiomyopathic Lentiginosis Cardio-Cutaneous Syndrome Lentiginosis Profusa Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome Generalized Lentiginosis Gorlin Syndrome Ii Lentiginosis Profusa Syndrome Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes Diffuse Lentiginosis Nsml Familial Multiple Lentigines Syndrome Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type Progressive Cardiomyopathic Lentiginosis Syndrome Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145923	Osunprotafib	Inhibitor	99.43%	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153446	Tegeprotafib	Inhibitor	99.30%	Unkown
HY-RS11415	PTPN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-145923B	Osunprotafib hydrochloride	Inhibitor	/	Unkown
HY-156606	Anticancer agent 142	Inhibitor	/	Unkown
HY-178716	PTPN2/1-IN-4		/	Unkown
HY-183937A	PD-305		/	Unkown
HY-N19872	Mukurozioside IIb		/	Unkown
HY-N19873	Mukurozioside IIa		/	Unkown
HY-P11604	C16 acid-I-{Lys(C10 diacid)}-KQELRRIGDEF	Inhibitor	/	Unkown
HY-RS17205	Ptpn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23657	Ptpn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PTPN1	VGNC	VGNC:45167
Macaca mulatta	PTPN1	VGNC	VGNC:76597
Rattus norvegicus	PTPN1	RGD	RGD:61965
Bos taurus	PTPN1	VGNC	VGNC:33529
Felis catus	PTPN1	VGNC	VGNC:69157
Mus musculus	PTPN1	MGD	MGI:97805
Others	PTPN1	NCBI