GRB2 - Grb2 growth factor receptor bound protein 2 Gene

Also Known as Ash-psi

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81504

Summary

Enables several functions, including epidermal growth factor receptor binding activity; Insulin Receptor substrate binding activity; and phosphotyrosine residue binding activity. Involved in aging. Part of protein-containing complex. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate Cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2). [provided by Alliance of Genome Resources, Apr 2022]

GRB2 Products (1)

mRNA Protein Name
NM_030846.2 NP_110473.2 growth factor receptor-bound protein 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
9259313 RGD
enables epidermal growth factor receptor binding IPI
IPI: Inferred from physical interaction
21258655 RGD
enables insulin receptor substrate binding IPI
IPI: Inferred from physical interaction
12891559 RGD
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
8910399 RGD
enables phosphotyrosine residue binding IPI
IPI: Inferred from physical interaction
9271418 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8940134 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
10973965 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
15272025 RGD
Cellular Component GO Annotation Evidence References Source
is active in presynapse IDA
IDA: Inferred from direct assay
8022809 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
10973965 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth factor receptor-bound protein 2

  • SH2/SH3 adapter GRB2

  • adapter protein GRB2

  • growth factor receptor-bound protein 2-like

  • protein Ash

GRB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Grb2 P62994 PDE6G Homo sapiens P18545
Y2H
16357825
Cross
Grb2 P62994 PTPN1 Homo sapiens P18031
Pull Down
8940134
Cross
Grb2 P62994 PTPN1 Homo sapiens P18031
Pull Down
12023880
Intra
Grb2 P62994 Ntrk1 Rattus norvegicus P35739
Y2H
10748052
Intra
Grb2 P62994 Ntrk1 Rattus norvegicus P35739
Pull Down
10748052
Intra
Grb2 P62994 Ntrk1 Rattus norvegicus P35739
CoIP
10748052
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-153495A Prexigebersen sodium Inhibitor 98.95% Phase 2
HY-153495 Prexigebersen / Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-129800 CGP78850 Inhibitor 99.47% Unkown
HY-146127A Grb2 SH2 domain inhibitor 1 TFA Inhibitor 99.62% Unkown
HY-146127 Grb2 SH2 domain inhibitor 1 Inhibitor 98.24% Unkown
HY-RS05780 GRB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N14349 Asterriquinone Inhibitor / Unkown
HY-RS17407 Grb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23861 Grb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens GRB2 NCBI NCBI:2885