Pex2 - peroxisomal biogenesis factor 2 Gene

Also Known as PAF-1; PMP35; Pxmp3; D3Ertd138e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19302

Summary

Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including bile acid biosynthetic process; Cholesterol homeostasis; and regulation of Cholesterol biosynthetic process. Predicted to be located in peroxisomal membrane. Predicted to be integral component of peroxisomal membrane. Predicted to be part of Cdc73/Paf1 complex. Is expressed in several structures, including brain and genitourinary system. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and peroxisome biogenesis disorder 5A. Orthologous to human PEX2 (peroxisomal biogenesis factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Pex2 Products (7)

mRNA Protein Name
NM_001163301.2 NP_001156773.1 peroxisome biogenesis factor 2
NM_001163302.2 NP_001156774.1 peroxisome biogenesis factor 2
NM_001163305.2 NP_001156777.1 peroxisome biogenesis factor 2
NM_001163306.2 NP_001156778.1 peroxisome biogenesis factor 2
NM_001267714.1 NP_001254643.1 peroxisome biogenesis factor 2
NM_001267715.1 NP_001254644.1 peroxisome biogenesis factor 2
NM_008994.4 NP_033020.2 peroxisome biogenesis factor 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within bile acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
14673138 MGI
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
14673138 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
12746876 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
12746876 MGI
involved in peroxisome organization IMP
IMP: Inferred from mutant phenotype
9382874 MGI
acts upstream of or within regulation of cholesterol biosynthetic process IMP
IMP: Inferred from mutant phenotype
14673138 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peroxisome biogenesis factor 2

  • Zellweger syndrome homolog

  • peroxin-2

  • peroxisomal membrane protein 3, 35 kDa

  • peroxisome assembly factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10348 PEX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21406 Pex2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27925 Pex2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pex2 NCBI NCBI:5828