Qki - quaking, KH domain containing RNA binding Gene

Also Known as Qk; l17Wis1; 1500005P18; l(17)-1Wis; 1110003F05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19317

Summary

Enables mRNA binding activity. Acts upstream of or within several processes, including long-chain fatty acid biosynthetic process; positive regulation of macromolecule metabolic process; and vasculogenesis. Located in cytoplasm; nucleus; and synapse. Is expressed in several structures, including alimentary system; central nervous system; craniocervical region bone; reproductive system; and sensory organ. Orthologous to human QKI (QKI, KH domain containing RNA binding). [provided by Alliance of Genome Resources, Apr 2022]

Qki Products (3)

mRNA Protein Name
NM_001159516.2 NP_001152988.1 protein quaking isoform 2
NM_001159517.2 NP_001152989.1 protein quaking isoform 1
NM_021881.3 NP_068681.1 protein quaking isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
21253564 MGI
enables mRNA 3'-UTR binding IMP
IMP: Inferred from mutant phenotype
31868295 MGI
enables mRNA binding IDA
IDA: Inferred from direct assay
20956316 MGI
enables mRNA binding IMP
IMP: Inferred from mutant phenotype
36627242 MGI
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
33942715 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon ensheathment IMP
IMP: Inferred from mutant phenotype
14169723 MGI
acts upstream of or within long-chain fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
1150661 MGI
involved in mRNA stabilization IDA
IDA: Inferred from direct assay
32732889 MGI
involved in microglia differentiation IMP
IMP: Inferred from mutant phenotype
33378678 MGI
acts upstream of or within myelination IMP
IMP: Inferred from mutant phenotype
1150661 MGI
involved in myofibroblast contraction IMP
IMP: Inferred from mutant phenotype
33397958 MGI
involved in negative regulation of 3'-UTR-mediated mRNA stabilization IMP
IMP: Inferred from mutant phenotype
31868295 MGI
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
32732889 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
31868295 MGI
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
20956316 MGI
involved in negative regulation of translation IMP
IMP: Inferred from mutant phenotype
31868295 MGI
involved in positive regulation of 3'-UTR-mediated mRNA stabilization IDA
IDA: Inferred from direct assay
28188285 MGI
involved in positive regulation of cholesterol biosynthetic process IMP
IMP: Inferred from mutant phenotype
33942715 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
1373175 MGI
involved in positive regulation of myelination IMP
IMP: Inferred from mutant phenotype
33942715 MGI
involved in positive regulation of oligodendrocyte differentiation IDA
IDA: Inferred from direct assay
20956316 MGI
involved in regulation of astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
33750804 MGI
involved in regulation of mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
29021242 MGI
involved in regulation of mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
33378678 MGI
acts upstream of or within spermatid development IGI
IGI: Inferred from genetic interaction
15148410 MGI
involved in spliceosome-depend formation of circular RNA IDA
IDA: Inferred from direct assay
37272356 MGI
acts upstream of or within vascular associated smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
14706070 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
11892011 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
20956316 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10506177 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
28188285 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10506177 MGI
is active in nucleus IMP
IMP: Inferred from mutant phenotype
31868295 MGI
located in nucleus IMP
IMP: Inferred from mutant phenotype
10506177 MGI
is active in synapse EXP
EXP: Inferred from Experiment
16452087 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16452087 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein quaking

  • QKI-5 protein

  • QKI-6 protein

  • QKI-7 protein

  • QKI-7b protein

  • lethal, Chr 17, U Wisconsin 1

  • quaking

Qki Antibodies

Cat. No. Product Name Application Reactivity
HY-P87046 QKI-7 Antibody (YA6739) WB Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS21287 Qki Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11500 QKI Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27806 Qki Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Qki NCBI NCBI:9444