Aldh1a2 - aldehyde dehydrogenase family 1, subfamily A2 Gene

Also Known as Raldh1; Raldh2; Aldh1a7

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19378

Summary

Enables 3-chloroallyl aldehyde dehydrogenase activity and retinal dehydrogenase activity. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and retinoid metabolic process. Predicted to be located in cytosol and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study DiGeorge syndrome. Orthologous to human ALDH1A2 (aldehyde dehydrogenase 1 family member A2). [provided by Alliance of Genome Resources, Apr 2022]

Aldh1a2 Products (1)

mRNA Protein Name
NM_009022.4 NP_033048.2 retinal dehydrogenase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 3-chloroallyl aldehyde dehydrogenase activity IDA
IDA: Inferred from direct assay
12610736 MGI
enables retinal dehydrogenase activity IDA
IDA: Inferred from direct assay
8797830 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within 9-cis-retinoic acid biosynthetic process IDA
IDA: Inferred from direct assay
11876656 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
17067568 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
15652703 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
14627725 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
15366004 MGI
acts upstream of or within cardiac muscle tissue development IMP
IMP: Inferred from mutant phenotype
9892670 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16368932 MGI
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
18816858 MGI
acts upstream of or within determination of bilateral symmetry IMP
IMP: Inferred from mutant phenotype
15731404 MGI
acts upstream of or within embryonic camera-type eye development IGI
IGI: Inferred from genetic interaction
17184764 MGI
acts upstream of or within embryonic digestive tract development IMP
IMP: Inferred from mutant phenotype
16806149 MGI
acts upstream of or within embryonic forelimb morphogenesis IMP
IMP: Inferred from mutant phenotype
15069081 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
14623241 MGI
acts upstream of or within face development IGI
IGI: Inferred from genetic interaction
17184764 MGI
acts upstream of or within face development IMP
IMP: Inferred from mutant phenotype
17184764 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
16368932 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
11245568 MGI
acts upstream of or within hindbrain development IMP
IMP: Inferred from mutant phenotype
15872003 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
16427040 MGI
acts upstream of or within morphogenesis of embryonic epithelium IMP
IMP: Inferred from mutant phenotype
15739227 MGI
acts upstream of or within neural crest cell development IGI
IGI: Inferred from genetic interaction
17067568 MGI
acts upstream of or within neural crest cell development IMP
IMP: Inferred from mutant phenotype
16368932 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
15652703 MGI
acts upstream of or within pancreas development IMP
IMP: Inferred from mutant phenotype
15739227 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20034106 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16368932 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20034106 MGI
acts upstream of or within proximal/distal pattern formation IMP
IMP: Inferred from mutant phenotype
14623241 MGI
acts upstream of or within regulation of vascular endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
14627725 MGI
acts upstream of or within retinal metabolic process IDA
IDA: Inferred from direct assay
12610736 MGI
acts upstream of or within retinoic acid metabolic process IDA
IDA: Inferred from direct assay
8797830 MGI
acts upstream of or within retinoic acid metabolic process IMP
IMP: Inferred from mutant phenotype
14623241 MGI
acts upstream of or within retinoic acid receptor signaling pathway IGI
IGI: Inferred from genetic interaction
15889094 MGI
acts upstream of or within retinoic acid receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15739227 MGI
acts upstream of or within ureter maturation IMP
IMP: Inferred from mutant phenotype
21521737 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

retinal dehydrogenase 2

  • RALDH 2

  • RALDH(II)

  • alcohol dehydrogenase family 1, subfamily A2

  • alcohol dehydrogenase family 1, subfamily A7

  • aldehyde dehydrogenase family 1 member A2

  • retinaldehyde dehydrogenase 2

  • retinaldehyde-specific dehydrogenase type 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W011094 Win 18446 Inhibitor 98.94% Unkown
HY-125085 ALDH3A1-IN-3 Inhibitor 99.43% Unkown
HY-122912 ALDH1A inhibitor 673A 99.15% Unkown
HY-135841 CM010 Inhibitor 99.70% Unkown
HY-139031 ALDH1A2-IN-1 Inhibitor 98.05% Unkown
HY-157567 FSI-TN42 Inhibitor 98.05% Unkown
HY-128299 ALDH3A1-IN-4 Inhibitor 99.91% Unkown
HY-139032 CM121 Inhibitor 99.95% Unkown
HY-158026 ALDH1A1-IN-5 Inhibitor / Unkown
HY-N11451 Lacto-N-fucopentaose III Activator 96.54% Unkown
HY-RS00561 Aldh1a1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS00563 ALDH1A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00567 ALDH1L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17028 Aldh1a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23472 Aldh1a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aldh1a2 NCBI NCBI:8854