Rpe65 - retinal pigment epithelium 65 Gene

Also Known as LCA2; RP20; rd12; 65kDa; Mord1; A930029L06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19892

Summary

Enables retinal isomerase activity. Acts upstream of or within several processes, including cellular response to electrical stimulus; Insulin Receptor signaling pathway; and retinal metabolic process. Located in cytoplasm; nucleus; and plasma membrane. Is expressed in eye; pelvic urothelial lining; pigmented retinal epithelium; and urothelium of ureter. Used to study Leber congenital amaurosis 2 and retinitis pigmentosa 20. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 2; retinitis pigmentosa; retinitis pigmentosa 20; and retinitis pigmentosa 87. Orthologous to human RPE65 (retinoid isomerohydrolase RPE65). [provided by Alliance of Genome Resources, Apr 2022]

Rpe65 Products (1)

mRNA Protein Name
NM_029987.2 NP_084263.2 retinoid isomerohydrolase

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21493626 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26404741 MGI
located in nucleus IDA
IDA: Inferred from direct assay
26404741 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
26404741 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

retinoid isomerohydrolase

  • all-trans-retinyl-palmitate hydrolase

  • lutein isomerase

  • meso-zeaxanthin isomerase

  • modifier of retinal degeneration 1

  • retinal pigment epithelium, 65 kDa

  • retinal pigment epithelium-specific 65 kDa protein

  • retinol isomerase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-19720A Emixustat hydrochloride Inhibitor 99.29% Phase 3
HY-19720 Emixustat 98.00% Phase 3

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149325 RPE65-IN-1 Inhibitor ≥98.0% Unkown
HY-119059 CU239 Inhibitor / Unkown
HY-175663 EYE-002 Inhibitor / Unkown
HY-175664 EYE-003 Inhibitor / Unkown
HY-RS12151 RPE65 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22780 Rpe65 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29294 Rpe65 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rpe65 NCBI NCBI:6121