APOBEC3A - apolipoprotein B mRNA editing enzyme catalytic subunit 3A Gene

Homo sapiens

Also known as A3A; ARP3; PHRBN; bK150C2.1

Gene ID: 200315 | Gene type: protein coding

About APOBEC3A

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,957,609-38,963,184 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 26 orthologues and 9 paralogues. Biased expression in bone marrow (RPKM 38.8), appendix (RPKM 13.8) and 5 other tissues.

Summary

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

APOBEC3A Products(2)

mRNA	Protein	Name
NM_001270406.2	NP_001257335.1	DNA dC->dU-editing enzyme APOBEC-3A isoform b
NM_145699.4	NP_663745.1	DNA dC->dU-editing enzyme APOBEC-3A isoform a

APOBEC3A Protein Structure

APOBEC_C

0
100
199 a.a.

Protein Preferred Names

Protein Names

DNA dC->dU-editing enzyme APOBEC-3A

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A

Recombinant APOBEC3A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72080	APOBEC3A Protein, Human (His-SUMO)	P31941 (M1-N199)	≥95%

Related Diseases

Diseases

Alias

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

Bone Leiomyosarcoma

Human T-Cell Leukemia Virus Type 1

Htlv-1

Human T Lymphotropic Virus Type 1

Plantar Wart

Verruca Plantaris	Verrucae On Sole Of Foot
Mosaic Plantar Warts

Epiphyseal Dysplasia, Multiple, 3

EDM3	Multiple Epiphyseal Dysplasia 3
Epiphyseal Dysplasia, Multiple, 3, With Or Without Myopathy	Multiple Epiphyseal Dysplasia 3 With Or Without Myopathy
Epiphyseal Dysplasia Multiple 3	Dysplasia, Epiphyseal, Multiple, Type 3

Psoriasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00836	APOBEC3A Human Pre-designed siRNA Set A		/	Unkown

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