Ryr3 - ryanodine receptor 3 Gene

Also Known as RYR-3; C230090H21

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20192

Summary

Predicted to enable calcium ion binding activity; calcium-induced calcium release activity; and ryanodine-sensitive calcium-release channel activity. Acts upstream of or within cellular calcium ion homeostasis and striated muscle contraction. Located in sarcoplasmic reticulum membrane. Part of junctional membrane complex. Is expressed in several structures, including central nervous system; diaphragm; hemolymphoid system; liver; and musculature. Orthologous to human RYR3 (ryanodine receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Ryr3 Products (1)

mRNA Protein Name
NM_001319156.1 NP_001306085.1 ryanodine receptor 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ryanodine-sensitive calcium-release channel activity IDA
IDA: Inferred from direct assay
9582272 MGI
enables ryanodine-sensitive calcium-release channel activity IMP
IMP: Inferred from mutant phenotype
8702664 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
9384575 MGI
acts upstream of or within striated muscle contraction IMP
IMP: Inferred from mutant phenotype
9384575 MGI
Cellular Component GO Annotation Evidence References Source
part of junctional membrane complex IDA
IDA: Inferred from direct assay
10444070 MGI
located in sarcoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
14592808 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ryanodine receptor 3

  • brain ryanodine receptor-calcium release channel

  • brain-type ryanodine receptor

  • calcium release channel

  • type 3 ryanodine receptor

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12542 Dantrolene Inhibitor 99.93% Yes
HY-12542A Dantrolene sodium hemiheptahydrate Inhibitor 99.79% Unkown
HY-14657 Dantrolene sodium Inhibitor 99.79% Yes

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149662 TMDJ-035 Inhibitor 99.92% Unkown
HY-113040A (17R,18S)-Epoxyeicosatetraenoic acid Inhibitor 93.0% Unkown
HY-RS12370 RYR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19158 Ryr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25647 Ryr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ryr3 NCBI NCBI:6263