Msr1 - macrophage scavenger receptor 1 Gene

Also Known as MSR; SR-A; Scvr; MRS-A; MSR-A; SR-AI; SR-AII; Scara1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20288

Summary

Enables amyloid-beta binding activity; cargo receptor activity; and low-density lipoprotein particle binding activity. Involved in several processes, including endocytosis; positive regulation of Cholesterol storage; and positive regulation of macrophage derived foam cell differentiation. Acts upstream of or within lipoprotein transport. Located in plasma membrane. Is expressed in several structures, including alimentary system; limb; neural tube; reproductive system; and yolk sac. Human ortholog(s) of this gene implicated in Barrett's esophagus; arteriosclerosis; and prostate Cancer. Orthologous to human MSR1 (macrophage scavenger receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Msr1 Products (2)

mRNA	Protein	Name
NM_001113326.2	NP_001106797.2	macrophage scavenger receptor types I and II isoform b
NM_031195.3	NP_112472.3	macrophage scavenger receptor types I and II isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables amyloid-beta binding	IGI IGI: Inferred from genetic interaction	11240025	MGI
enables cargo receptor activity	IGI IGI: Inferred from genetic interaction	22438044	MGI
enables low-density lipoprotein particle binding	IMP IMP: Inferred from mutant phenotype	12376530	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in amyloid-beta clearance	IGI IGI: Inferred from genetic interaction	22438044	MGI
involved in amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	11240025	MGI
involved in cholesterol transport	IMP IMP: Inferred from mutant phenotype	12376530	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	17148552	MGI
acts upstream of or within lipoprotein transport	IMP IMP: Inferred from mutant phenotype	17148552	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	11240025	MGI
involved in phagocytosis, engulfment	IGI IGI: Inferred from genetic interaction	22438044	MGI
involved in plasma lipoprotein particle clearance	IMP IMP: Inferred from mutant phenotype	12376530	MGI
involved in positive regulation of cholesterol storage	IMP IMP: Inferred from mutant phenotype	12376530	MGI
involved in positive regulation of macrophage derived foam cell differentiation	IGI IGI: Inferred from genetic interaction	12376530	MGI
involved in receptor-mediated endocytosis	IGI IGI: Inferred from genetic interaction	22438044	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	11240025	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
macrophage scavenger receptor types I and II	macrophage acetylated LDL receptor I and II scavenger receptor type A

Recombinant Msr1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76782	CD204/MSR1 Protein, Mouse (HEK293, His)	AAH03814.1 (W83-V354)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18234A	Leupeptin hemisulfate		99.39%	Yes
HY-18234C	Leupeptin Ac-LL hydrochloride		95.0%	Unkown
HY-RS18248	Msr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-18234	Leupeptin		/	Unkown
HY-18234B	Leupeptin Ac-LL		/	Unkown
HY-RS08724	MSR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183478	Leupeptin hydrochloride		/	Unkown
HY-RS24728	Msr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992269	Anti-MSR1 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Msr1	NCBI	NCBI:4481