Sema3f - sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F Gene

Also Known as Sema4; Semak

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20350

Summary

Enables chemorepellent activity. Involved in nervous system development; regulation of postsynapse organization; and ventral trunk neural crest cell migration. Acts upstream of or within generation of neurons; negative chemotaxis; and neural crest cell migration. Located in extracellular space. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human SEMA3F (semaphorin 3F). [provided by Alliance of Genome Resources, Apr 2022]

Sema3f Products (6)

mRNA Protein Name
NM_001311151.3 NP_001298080.1 semaphorin-3F isoform 1 precursor
NM_001379496.2 NP_001366425.1 semaphorin-3F isoform 2 precursor
NM_001405023.1 NP_001391952.1 semaphorin-3F isoform 4 precursor
NM_001405024.1 NP_001391953.1 semaphorin-3F isoform 5 precursor
NM_001405025.2 NP_001391954.1 semaphorin-3F isoform 1 precursor
NM_011349.4 NP_035479.2 semaphorin-3F isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables chemorepellent activity IDA
IDA: Inferred from direct assay
11683995 MGI
Biological Process GO Annotation Evidence Referencias Source
acts upstream of axon extension involved in axon guidance IDA
IDA: Inferred from direct assay
9753685 MGI
acts upstream of axon extension involved in axon guidance IGI
IGI: Inferred from genetic interaction
11683995 MGI
involved in axon extension involved in axon guidance IMP
IMP: Inferred from mutant phenotype
22790009 MGI
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
12435358 MGI
involved in branchiomotor neuron axon guidance IMP
IMP: Inferred from mutant phenotype
18804103 MGI
involved in facial nerve structural organization IMP
IMP: Inferred from mutant phenotype
18804103 MGI
acts upstream of or within negative chemotaxis IDA
IDA: Inferred from direct assay
16319111 MGI
acts upstream of or within negative chemotaxis IGI
IGI: Inferred from genetic interaction
11683995 MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance IDA
IDA: Inferred from direct assay
9753685 MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance IGI
IGI: Inferred from genetic interaction
11683995 MGI
involved in nerve development IMP
IMP: Inferred from mutant phenotype
22790009 MGI
involved in neural crest cell migration involved in autonomic nervous system development IMP
IMP: Inferred from mutant phenotype
19386662 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
20010807 MGI
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
20010807 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
18804103 MGI
involved in sympathetic ganglion development IMP
IMP: Inferred from mutant phenotype
22790009 MGI
involved in sympathetic neuron projection extension IMP
IMP: Inferred from mutant phenotype
22790009 MGI
involved in sympathetic neuron projection guidance IMP
IMP: Inferred from mutant phenotype
22790009 MGI
involved in trigeminal nerve structural organization IMP
IMP: Inferred from mutant phenotype
18804103 MGI
acts upstream of or within trunk neural crest cell migration IMP
IMP: Inferred from mutant phenotype
16319111 MGI
involved in ventral trunk neural crest cell migration IMP
IMP: Inferred from mutant phenotype
19386662 MGI
Cellular Component GO Annotation Evidence Referencias Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20010807 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
20010807 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

semaphorin-3F

  • semaphorin IV

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS12655 SEMA3F Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20594 Sema3f Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27102 Sema3f Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sema3f NCBI NCBI:6405