SEMA3F - semaphorin 3F Gene

Also Known as SEMA4; SEMAK; SEMA-IV

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6405

About SEMA3F

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,155,058-50,189,075 (from NCBI)

This gene has 9 transcripts (splice variants), 273 orthologues and 19 paralogues. Broad expression in skin (RPKM 21.7), esophagus (RPKM 16.4) and 19 other tissues.

Summary

This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce Apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

SEMA3F Products (3)

mRNA Protein Name
NM_001318798.2 NP_001305727.1 semaphorin-3F isoform 3
NM_001318800.2 NP_001305729.1 semaphorin-3F isoform 2 precursor
NM_004186.5 NP_004177.3 semaphorin-3F isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables chemorepellent activity IDA
IDA: Inferred from direct assay
15814794 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
15814794 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEMA3F Protein Structure

Sema

Sema: Sema domain (57 - 529)

  • 0
  • 200
  • 400
  • 600
  • 785 a.a.
Protein Preferred Names Protein Names

semaphorin-3F

  • sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

Recombinant SEMA3F Proteins

Cat. No. Product Name Accession Purity
HY-P71674 Semaphorin-3F/SEMA3F Protein, Human (HEK293, His-Myc) Q13275 (S19-T785) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Neuroma
Megacolon

  • Dilatation Of Colon
Wallerian Degeneration

  • Wallerian Degeneration Of The Pyramidal Tract
Cone-Rod Dystrophy 10

  • CORD10

  • Dystrophy, Cone-Rod, Type 10
Brachial Plexus Lesion

  • Brachial Plexus Injuries

  • Brachial Plexus Lesions
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Kallmann Syndrome

  • Hypogonadism With Anosmia

  • Kallman'S Syndrome

  • Anosmic Hypogonadism

  • Anosmic Idiopathic Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism And Anosmia

  • Hypogonadotropic Hypogonadism-Anosmia Syndrome

  • Olfacto-Genital Pathological Sequence

  • Familial Hypogonadism With Anosmia

  • Kallman Syndrome

  • Dysplasia Olfactogenitalis Of De Morsier

  • Kallmann'S Syndrome

  • Congenital Hypogonadotropic Hypogonadism With Anosmia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12655 SEMA3F Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20594 Sema3f Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27102 Sema3f Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SEMA3F VGNC VGNC:77164
Rattus norvegicus SEMA3F RGD RGD:1308514
Canis familiaris SEMA3F VGNC VGNC:45992
Mus musculus SEMA3F MGD MGI:1096347
Bos taurus SEMA3F VGNC VGNC:34431
Felis catus SEMA3F VGNC VGNC:64990
Others SEMA3F NCBI