Sema4d - sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Gene

Also Known as CD100; Semaj; Semcl2; coll-4; Semacl2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20354

Summary

Enables semaphorin receptor binding activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of inhibitory synapse assembly; and regulation of phosphate metabolic process. Acts upstream of or within positive regulation of axonogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and respiratory system. Orthologous to human SEMA4D (semaphorin 4D). [provided by Alliance of Genome Resources, Apr 2022]

Sema4d Products (15)

mRNA Protein Name
NM_001281880.2 NP_001268809.1 semaphorin-4D isoform 1 precursor
NM_001378313.1 NP_001365242.1 semaphorin-4D isoform 1 precursor
NM_001378314.1 NP_001365243.1 semaphorin-4D isoform 1 precursor
NM_001378315.1 NP_001365244.1 semaphorin-4D isoform 1 precursor
NM_001378316.1 NP_001365245.1 semaphorin-4D isoform 1 precursor
NM_001378317.1 NP_001365246.1 semaphorin-4D isoform 2 precursor
NM_001378318.1 NP_001365247.1 semaphorin-4D isoform 2 precursor
NM_001378319.1 NP_001365248.1 semaphorin-4D isoform 2 precursor
NM_001378320.1 NP_001365249.1 semaphorin-4D isoform 3 precursor
NM_001378321.1 NP_001365250.1 semaphorin-4D isoform 3 precursor
NM_001378322.1 NP_001365251.1 semaphorin-4D isoform 3 precursor
NM_001378323.1 NP_001365252.1 semaphorin-4D isoform 3 precursor
NM_001378324.1 NP_001365253.1 semaphorin-4D isoform 4 precursor
NM_001378325.1 NP_001365254.1 semaphorin-4D isoform 5
NM_013660.5 NP_038688.2 semaphorin-4D isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
2917992 MGI
enables receptor ligand activity IDA
IDA: Inferred from direct assay
22019888 MGI
enables semaphorin receptor binding IPI
IPI: Inferred from physical interaction
22019888 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
15330859 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of axonogenesis IDA
IDA: Inferred from direct assay
15330859 MGI
acts upstream of axonogenesis IGI
IGI: Inferred from genetic interaction
15330859 MGI
involved in bone trabecula morphogenesis IMP
IMP: Inferred from mutant phenotype
22019888 MGI
involved in negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
22019888 MGI
involved in negative regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
22019888 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22019888 MGI
involved in ossification involved in bone maturation IMP
IMP: Inferred from mutant phenotype
22019888 MGI
involved in positive regulation of Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
22019888 MGI
acts upstream of or within positive regulation of axonogenesis IDA
IDA: Inferred from direct assay
15330859 MGI
acts upstream of or within positive regulation of axonogenesis IGI
IGI: Inferred from genetic interaction
15330859 MGI
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
22019888 MGI
involved in positive regulation of inhibitory synapse assembly IDA
IDA: Inferred from direct assay
23699507 MGI
involved in positive regulation of inhibitory synapse assembly IMP
IMP: Inferred from mutant phenotype
29981480 MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
22019888 MGI
involved in regulation of synapse assembly IDA
IDA: Inferred from direct assay
24036351 MGI
involved in regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
24036351 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
22019888 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
24036351 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
24036351 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
22019888 MGI
part of semaphorin receptor complex IMP
IMP: Inferred from mutant phenotype
22019888 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

semaphorin-4D

  • M-sema G

  • sema J

  • semaphorin H

  • semaphorin-C-like 2

  • semaphorin-J

Recombinant Sema4d Proteins

Cat. No. Product Name Accession Purity
HY-P72478 Semaphorin-4D/SEMA4D Protein, Mouse (HEK293, Fc) O09126 (F24-M711) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P74563 Semaphorin-4D/SEMA4D Protein, Mouse (HEK293, His) O09126 (M1-R733) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700429 Semaphorin-4D/SEMA4D Protein, Mouse (HEK293, mFc) O09126 (F24-R733) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12660 SEMA4D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16931 Sema4d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23374 Sema4d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sema4d NCBI NCBI:10507