SEMA4D - semaphorin 4D Gene

Homo sapiens

Also known as A8; GR3; BB18; CD100; COLL4; SEMAJ; coll-4; C9orf164; M-sema-G

Gene ID: 10507 | Gene type: protein coding

About SEMA4D

Cytogenetic location: 9q22.2 Genomic coordinates (GRCh38): 9:89,360,787-89,498,113 (from NCBI)

This gene has 24 transcripts (splice variants), 192 orthologues, 19 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 12.0), appendix (RPKM 8.6) and 22 other tissues.

Summary

Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including positive regulation of phosphatidylinositol 3-kinase signaling; regulation of neuron projection development; and regulation of phosphate metabolic process. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SEMA4D Products(11)

mRNA	Protein	Name
NM_001142287.2	NP_001135759.1	semaphorin-4D isoform 2 precursor
NM_001371194.2	NP_001358123.1	semaphorin-4D isoform 1 precursor
NM_001371195.1	NP_001358124.1	semaphorin-4D isoform 1 precursor
NM_001371196.1	NP_001358125.1	semaphorin-4D isoform 1 precursor
NM_001371197.1	NP_001358126.1	semaphorin-4D isoform 1 precursor
NM_001371198.1	NP_001358127.1	semaphorin-4D isoform 2 precursor
NM_001371199.1	NP_001358128.1	semaphorin-4D isoform 2 precursor
NM_001371200.1	NP_001358129.1	semaphorin-4D isoform 2 precursor
NM_001371201.1	NP_001358130.1	semaphorin-4D isoform 2 precursor
NM_001371202.1	NP_001358131.1	semaphorin-4D isoform 3 precursor
NM_006378.4	NP_006369.3	semaphorin-4D isoform 1 precursor

SEMA4D Protein Structure

Sema

PSI

0
200
400
600
800
862 a.a.

Protein Preferred Names

Protein Names

semaphorin-4D

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

Recombinant SEMA4D Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7774	Semaphorin-4D/SEMA4D Protein, Human (713a.a, HEK293, His)	Q92854 (M22-R734)	≥95%
HY-P74564	Semaphorin-4D/SEMA4D Protein, Human (734a.a, HEK293, His)	Q92854 (M1-R734)	≥95%
HY-P74565	Semaphorin-4D/SEMA4D Protein, Human (HEK293, hFc)	Q92854 (M1-R734)	≥95%
HY-P77194	Semaphorin-4D/SEMA4D Protein, Rhesus Macaque (HEK293, His)	EHH24221.1 (M1-R734)	≥95%
HY-P78202	Semaphorin-4D/SEMA4D Protein, Human (Biotinylated, HEK293, His-Avi)	Q92854 (M22-R734)	≥95%
HY-P78512	Semaphorin-4D/SEMA4D Protein, Human (HEK293, His-Avi)	Q92854 (M22-R734)	≥95%

Related Diseases

Diseases

Alias

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Osteonecrosis Of The Jaw

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12660	SEMA4D Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SEMA4D	VGNC	VGNC:34436
Canis familiaris	SEMA4D	VGNC	VGNC:53974
Mus musculus	SEMA4D	MGD	MGI:109244
Macaca mulatta	SEMA4D	VGNC	VGNC:77166
Felis catus	SEMA4D	VGNC	VGNC:64995
Rattus norvegicus	SEMA4D	RGD	RGD:1310554
Macaca fascicularis	SEMA4D	NCBI
Others	SEMA4D	NCBI

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