SEMA4D - semaphorin 4D Gene

Also Known as A8; GR3; BB18; CD100; COLL4; SEMAJ; coll-4; C9orf164; M-sema-G

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10507

About SEMA4D

Cytogenetic location: 9q22.2 Genomic coordinates (GRCh38): 9:89,360,787-89,498,113 (from NCBI)

This gene has 24 transcripts (splice variants), 192 orthologues, 19 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 12.0), appendix (RPKM 8.6) and 22 other tissues.

Summary

Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including positive regulation of phosphatidylinositol 3-kinase signaling; regulation of neuron projection development; and regulation of phosphate metabolic process. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SEMA4D Products (11)

mRNA	Protein	Name
NM_001142287.2	NP_001135759.1	semaphorin-4D isoform 2 precursor
NM_001371194.2	NP_001358123.1	semaphorin-4D isoform 1 precursor
NM_001371195.1	NP_001358124.1	semaphorin-4D isoform 1 precursor
NM_001371196.1	NP_001358125.1	semaphorin-4D isoform 1 precursor
NM_001371197.1	NP_001358126.1	semaphorin-4D isoform 1 precursor
NM_001371198.1	NP_001358127.1	semaphorin-4D isoform 2 precursor
NM_001371199.1	NP_001358128.1	semaphorin-4D isoform 2 precursor
NM_001371200.1	NP_001358129.1	semaphorin-4D isoform 2 precursor
NM_001371201.1	NP_001358130.1	semaphorin-4D isoform 2 precursor
NM_001371202.1	NP_001358131.1	semaphorin-4D isoform 3 precursor
NM_006378.4	NP_006369.3	semaphorin-4D isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	20877282	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20877282	GOA
enables semaphorin receptor binding	IPI IPI: Inferred from physical interaction	15218527	GOA
enables signaling receptor activity	IDA IDA: Inferred from direct assay	15613544	GOA
enables signaling receptor binding	IDA IDA: Inferred from direct assay	11254688	GOA
enables transmembrane signaling receptor activity	IMP IMP: Inferred from mutant phenotype	20877282	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in leukocyte aggregation	IMP IMP: Inferred from mutant phenotype	8876214	GOA
involved in negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	15218527	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22019888	GOA
involved in ossification involved in bone maturation	IMP IMP: Inferred from mutant phenotype	22019888	GOA
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	19788569	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	16055703	GOA
involved in positive regulation of collateral sprouting	IMP IMP: Inferred from mutant phenotype	19788569	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	16055703	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	16055703	GOA
involved in regulation of cell projection organization	IMP IMP: Inferred from mutant phenotype	20877282	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	20877282	GOA
involved in regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	19788569	GOA
involved in semaphorin-plexin signaling pathway	IDA IDA: Inferred from direct assay	15218527	GOA
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	19788569	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	8876214	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEMA4D Protein Structure

Sema

PSI

ig

0
200
400
600
800
862 a.a.

Protein Preferred Names	Protein Names
semaphorin-4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

Recombinant SEMA4D Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7774	Semaphorin-4D/SEMA4D Protein, Human (HEK293, His)	Q92854-1 (M22-R734)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74565	Semaphorin-4D/SEMA4D Protein, Human (HEK293, hFc)	AAH54500.1 (M22-R734)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P77194	Semaphorin-4D/SEMA4D Protein, Rhesus Macaque (HEK293, His)	EHH24221.1 (M22-R734)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78202	Semaphorin-4D/SEMA4D Protein, Human (Biotinylated, HEK293, His-Avi)	Q92854-1 (M22-R734)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78512	Semaphorin-4D/SEMA4D Protein, Human (HEK293, His-Avi)	Q92854-1 (M22-R734)	≥ 95%, as determined by Bis-Tris PAGE.

SEMA4D Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82177	Semaphorin 4D Antibody (YA1922)	WB, ICC/IF	Human
HY-P82177A	Semaphorin 4D Antibody (YA1922)(PBS only)	WB, ICC/IF	Human
HY-P84710	Semaphorin 4D Antibody (YA4407)	IHC-P, FC, ELISA	Human
HY-P84710A	Semaphorin 4D Antibody (YA4407)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Cholangitis, Primary Sclerosing	Primary Sclerosing Cholangitis PSC Sclerosing Cholangitis Cholangitis, Sclerosing Cholangitis Primary Sclerosing Psc - [Primary Sclerosing Cholangitis]
Osteonecrosis Of The Jaw
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12660	SEMA4D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16931	Sema4d Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23374	Sema4d Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SEMA4D	VGNC	VGNC:34436
Canis familiaris	SEMA4D	VGNC	VGNC:53974
Mus musculus	SEMA4D	MGD	MGI:109244
Macaca mulatta	SEMA4D	VGNC	VGNC:77166
Felis catus	SEMA4D	VGNC	VGNC:64995
Rattus norvegicus	SEMA4D	RGD	RGD:1310554
Others	SEMA4D	NCBI