Semaphorin 4D Antibody (YA4407)
(Synonyms: SEMA4D; SEMAJ; coll-4; C9orf164; M-sema-G)Semaphorin 4D Antibody (YA4407) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Semaphorin 4D.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
Semaphorin 4D Antibody (YA4407) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Semaphorin 4D.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 120 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 96 kDa
Purified recombinant fragment of human CD100 (AA: extra 590-734) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Semaphorin 4D cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner. Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway[1][2][3][4].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:This gene is highly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus, and also expressed at lower levels in the testes, brain, kidneys, small intestine, prostate, heart, placenta, lungs, and pancreas, but is not expressed in the colon and liver. -
Isoforms & Post-Translational Modification
Q92854 has 2 isomers: Q92854-1: 96150 Da (predicted); Q92854-2: 82164 Da (predicted).
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Subunit
Homodimer (PubMed:20877282). Interacts with PLXNB1 (PubMed:10520995)
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SwissProt ID
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Synonyms
SEMA4D; SEMAJ; coll-4; C9orf164; M-sema-G
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