Sema7a - sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A Gene

Also Known as Semal; CDw108; sema L; sema K1; H-Sema-L; M-Sema-L; H-Sema K1; 2900057C09Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 20361

Summary

Enables Integrin binding activity. Involved in several processes, including integrin-mediated signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of macrophage cytokine production. Acts upstream of or within nervous system development and positive regulation of protein phosphorylation. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human SEMA7A (semaphorin 7A (John Milton Hagen blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Sema7a Products (1)

mRNA Protein Name
NM_011352.3 NP_035482.1 semaphorin-7A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables integrin binding IPI
IPI: Inferred from physical interaction
17377534 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within axon extension IDA
IDA: Inferred from direct assay
12879062 MGI
acts upstream of or within axon extension IGI
IGI: Inferred from genetic interaction
12879062 MGI
acts upstream of or within axon extension IMP
IMP: Inferred from mutant phenotype
12879062 MGI
involved in integrin-mediated signaling pathway IDA
IDA: Inferred from direct assay
17377534 MGI
acts upstream of or within neuron projection development IMP
IMP: Inferred from mutant phenotype
12879062 MGI
acts upstream of or within olfactory lobe development IDA
IDA: Inferred from direct assay
12879062 MGI
acts upstream of or within olfactory lobe development IMP
IMP: Inferred from mutant phenotype
12879062 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
17377534 MGI
acts upstream of or within positive regulation of axon extension IDA
IDA: Inferred from direct assay
12879062 MGI
involved in positive regulation of macrophage cytokine production IDA
IDA: Inferred from direct assay
17377534 MGI
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
12879062 MGI
acts upstream of protein phosphorylation IDA
IDA: Inferred from direct assay
12879062 MGI
involved in regulation of inflammatory response IDA
IDA: Inferred from direct assay
17377534 MGI
involved in regulation of synapse maturation IDA
IDA: Inferred from direct assay
25201975 MGI
involved in regulation of synapse maturation IMP
IMP: Inferred from mutant phenotype
25201975 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
25201975 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
25201975 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
17377534 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
25201975 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

semaphorin-7A

  • semaphorin-K1

  • semaphorin-L

Recombinant Sema7a Proteins

製品番号 製品名 アクセッション番号 純度
HY-P78035 Semaphorin-7A/SEMA7A Protein, Mouse (HEK293, His, solution) Q9QUR8 (Q45-A646) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS12668 SEMA7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17855 Sema7a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24324 Sema7a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Sema7a NCBI NCBI:8482