Sfrp1 - secreted frizzled-related protein 1 Gene

Also Known as sFRP-1; 2210415K03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20377

About Sfrp1

Chromosome 8: 23,901,518-23,939,648 forward strand.GRCm39:CM001001.3

This gene has 1 transcript (splice variant), 223 orthologues, 15 paralogues and is associated with 15 phenotypes. Ubiquitous expression in kidney adult (RPKM 23.7), CNS E11.5 (RPKM 22.8) and 26 other tissues.

Summary

Predicted to enable several functions, including Wnt-protein binding activity; Frizzled binding activity; and heparin binding activity. Involved in several processes, including cellular response to X-ray; cellular response to estrogen stimulus; and negative regulation of B cell differentiation. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human SFRP1 (secreted Frizzled related protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Sfrp1 Products (1)

mRNA Protein Name
NM_013834.3 NP_038862.2 secreted frizzled-related protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19188438 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
19850029 MGI
acts upstream of or within Wnt signaling pathway involved in somitogenesis IGI
IGI: Inferred from genetic interaction
18257070 MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IDA
IDA: Inferred from direct assay
18371946 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
16467359 MGI
acts upstream of or within bone trabecula formation IMP
IMP: Inferred from mutant phenotype
14976225 MGI
acts upstream of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
18257070 MGI
involved in cellular response to X-ray IDA
IDA: Inferred from direct assay
19778523 MGI
involved in cellular response to estrogen stimulus IDA
IDA: Inferred from direct assay
18941195 MGI
acts upstream of or within convergent extension involved in somitogenesis IGI
IGI: Inferred from genetic interaction
18257070 MGI
acts upstream of or within development of primary male sexual characteristics IGI
IGI: Inferred from genetic interaction
19100252 MGI
acts upstream of or within digestive tract morphogenesis IGI
IGI: Inferred from genetic interaction
19300477 MGI
involved in dopaminergic neuron differentiation IDA
IDA: Inferred from direct assay
22535492 MGI
acts upstream of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
14976225 MGI
acts upstream of or within female gonad development IGI
IGI: Inferred from genetic interaction
19100252 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
19664990 MGI
acts upstream of or within male gonad development IGI
IGI: Inferred from genetic interaction
19100252 MGI
involved in negative regulation of B cell differentiation IMP
IMP: Inferred from mutant phenotype
18941195 MGI
acts upstream of or within negative regulation of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
19850029 MGI
acts upstream of or within negative regulation of JUN kinase activity IGI
IGI: Inferred from genetic interaction
19300477 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19300477 MGI
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
16149051 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
17462603 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19850029 MGI
acts upstream of or within negative regulation of ossification IMP
IMP: Inferred from mutant phenotype
19254787 MGI
acts upstream of or within negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
14976225 MGI
acts upstream of or within negative regulation of osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
14976225 MGI
acts upstream of or within negative regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
14976225 MGI
acts upstream of or within neural crest cell fate commitment IMP
IMP: Inferred from mutant phenotype
20130188 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
19850029 MGI
acts upstream of or within neural tube development IGI
IGI: Inferred from genetic interaction
19850029 MGI
acts upstream of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
14976225 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
14976225 MGI
acts upstream of or within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
IMP: Inferred from mutant phenotype
18371946 MGI
acts upstream of or within regulation of branching involved in prostate gland morphogenesis IMP
IMP: Inferred from mutant phenotype
18371946 MGI
acts upstream of or within regulation of establishment of planar polarity IGI
IGI: Inferred from genetic interaction
19300477 MGI
involved in regulation of midbrain dopaminergic neuron differentiation IGI
IGI: Inferred from genetic interaction
22290867 MGI
involved in regulation of neuron projection development IDA
IDA: Inferred from direct assay
22290867 MGI
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
19778523 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
19664990 MGI
involved in somitogenesis IEP
IEP: Inferred from expression pattern
10654605 MGI
acts upstream of or within somitogenesis IGI
IGI: Inferred from genetic interaction
16467359 MGI
involved in stromal-epithelial cell signaling involved in prostate gland development IEP
IEP: Inferred from expression pattern
16288033 MGI
involved in ureteric bud development IEP
IEP: Inferred from expression pattern
16545622 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sfrp1 Protein Structure

CRD_SFRP1

CRD_SFRP1: cd07443 (51 - 174)

NTR_Sfrp1_like

NTR_Sfrp1_like: cd03580 (182 - 305)

  • 0
  • 100
  • 200
  • 300
  • 314 a.a.
Protein Preferred Names Protein Names

secreted frizzled-related protein 1

  • secreted frizzled-related sequence protein 1

Recombinant Sfrp1 Proteins

Cat. No. Product Name Accession Purity
HY-P73413 SFRP1 Protein, Mouse (CHO, His) AAC53145.1 (S32-K314) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10858 WAY 316606 99.24% Unkown
HY-117738 Benarthin Inhibitor 95.79% Unkown
HY-10860 WAY-362692 99.91% Unkown
HY-10858A WAY 316606 hydrochloride 98.04% Unkown
HY-202887 BCN512 Inhibitor 99.77% Unkown
HY-RS12772 SFRP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12773 Sfrp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12774 Sfrp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180876 SFRP1 modulator-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sfrp1 NCBI NCBI:6422