Frzb - frizzled-related protein Gene

Also Known as Frp; Sfrp3; fritz; frzb-1; frezzled

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20378

Summary

Enables Wnt-protein binding activity. Involved in negative regulation of Wnt signaling pathway. Acts upstream of or within several processes, including animal organ development; negative regulation of cartilage development; and negative regulation of cell differentiation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human FRZB (Frizzled related protein). [provided by Alliance of Genome Resources, Apr 2022]

Frzb Products (1)

mRNA Protein Name
NM_011356.4 NP_035486.1 secreted frizzled-related protein 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables Wnt-protein binding IDA
IDA: Inferred from direct assay
9178261 MGI
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
17462603 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9096311 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cochlea morphogenesis IGI
IGI: Inferred from genetic interaction
17433286 MGI
acts upstream of or within convergent extension involved in organogenesis IGI
IGI: Inferred from genetic interaction
17433286 MGI
acts upstream of epithelial cell development IDA
IDA: Inferred from direct assay
19562671 MGI
acts upstream of hepatocyte differentiation IDA
IDA: Inferred from direct assay
19562671 MGI
acts upstream of or within inner ear morphogenesis IDA
IDA: Inferred from direct assay
18991062 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
18991062 MGI
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
9178261 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
17433286 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19961844 MGI
acts upstream of or within negative regulation of cartilage development IGI
IGI: Inferred from genetic interaction
18991062 MGI
acts upstream of or within negative regulation of cell development IDA
IDA: Inferred from direct assay
19562671 MGI
acts upstream of or within negative regulation of hepatocyte differentiation IDA
IDA: Inferred from direct assay
19562671 MGI
involved in neural crest cell differentiation IEP
IEP: Inferred from expression pattern
10654605 MGI
involved in somite development IEP
IEP: Inferred from expression pattern
10654605 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

secreted frizzled-related protein 3

  • frizzled-related protein 1

  • secreted frizzled-related sequence protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05116 FRZB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19333 Frzb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25824 Frzb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Frzb NCBI NCBI:2487