Sfrp4 - secreted frizzled-related protein 4 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20379

Summary

Predicted to enable Wnt-protein binding activity. Involved in bone morphogenesis; negative regulation of Wnt signaling pathway; and regulation of BMP signaling pathway. Predicted to be located in cell surface and nucleus. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; brain; eye; lung; and urinary system. Human ortholog(s) of this gene implicated in metaphyseal dysplasia. Orthologous to human SFRP4 (secreted Frizzled related protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Sfrp4 Products (1)

mRNA Protein Name
NM_016687.3 NP_057896.1 secreted frizzled-related sequence protein 4 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in bone morphogenesis IMP
IMP: Inferred from mutant phenotype
27355534 MGI
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
27355534 MGI
involved in negative regulation of non-canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
27355534 MGI
involved in regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
27355534 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

secreted frizzled-related sequence protein 4

  • FRP-4

  • frizzled-related protein 4

  • sFRP-4

Recombinant Sfrp4 Proteins

Cat. No. Product Name Accession Purity
HY-P74550 SFRP4 Protein, Mouse (HEK293, His) Q9Z1N6/NP_057896.1 (V19-S351) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12776 SFRP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17510 Sfrp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23967 Sfrp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sfrp4 NCBI NCBI:6424