Shmt1 - serine hydroxymethyltransferase 1 (soluble) Gene

Also Known as Shmt; mshmt; mshmt1; mshmt2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20425

Summary

Enables glycine hydroxymethyltransferase activity. Involved in dTMP biosynthetic process and tetrahydrofolate interconversion. Acts upstream of or within cellular response to Leukemia Inhibitory Factor. Located in nucleus. Is expressed in several structures, including alimentary system; brain ventricular layer; genitourinary system; liver and biliary system; and skin. Human ortholog(s) of this gene implicated in breast Cancer. Orthologous to human SHMT1 (serine hydroxymethyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Shmt1 Products (1)

mRNA Protein Name
NM_009171.2 NP_033197.2 serine hydroxymethyltransferase, cytosolic

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycine hydroxymethyltransferase activity IGI
IGI: Inferred from genetic interaction
19513116 MGI
enables glycine hydroxymethyltransferase activity IMP
IMP: Inferred from mutant phenotype
19513116 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in dTMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
19513116 MGI
involved in tetrahydrofolate interconversion IMP
IMP: Inferred from mutant phenotype
19513116 MGI
Cellular Component GO Annotation Evidence References Source
is active in nucleus IDA
IDA: Inferred from direct assay
19513116 MGI
is active in nucleus IGI
IGI: Inferred from genetic interaction
19513116 MGI
located in nucleus IMP
IMP: Inferred from mutant phenotype
19513116 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine hydroxymethyltransferase, cytosolic

  • glycine hydroxymethyltransferase

  • serine methylase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-178432 SHMT2-IN-1 Inhibitor / Unkown
HY-148545 SHMT-IN-3 Inhibitor ≥98.0% Unkown
HY-177092 AGF347 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Shmt1 NCBI NCBI:6470