Slc2a1 - solute carrier family 2 (facilitated glucose transporter), member 1 Gene

Also Known as Glut1; Glut-1; M100200; Rgsc200

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20525

About Slc2a1

Chromosome 4: 118,965,908-118,995,180 forward strand.GRCm39:CM000997.3

This gene has 5 transcripts (splice variants), 374 orthologues, 11 paralogues and is associated with 12 phenotypes. Broad expression in liver E14.5 (RPKM 161.1), placenta adult (RPKM 14.1) and 25 other tissues.

Summary

Enables D-glucose transmembrane transporter activity and dehydroascorbic acid transmembrane transporter activity. Involved in dehydroascorbic acid transport and glucose transmembrane transport. Acts upstream of or within cellular response to glucose starvation. Located in several cellular components, including basolateral plasma membrane; female pronucleus; and photoreceptor inner segment. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease (multiple); carbohydrate metabolic disorder; myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc2a1 Products (1)

mRNA Protein Name
NM_011400.3 NP_035530.2 solute carrier family 2, facilitated glucose transporter member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-glucose transmembrane transporter activity IDA
IDA: Inferred from direct assay
18668520 MGI
enables dehydroascorbic acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
18668520 MGI
enables fucose transmembrane transporter activity IDA
IDA: Inferred from direct assay
36423686 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15975910 MGI
Biological Process GO Annotation Evidence References Source
involved in D-glucose transmembrane transport IDA
IDA: Inferred from direct assay
18668520 MGI
acts upstream of or within cellular response to glucose starvation IDA
IDA: Inferred from direct assay
11259273 MGI
involved in dehydroascorbic acid transport IDA
IDA: Inferred from direct assay
18668520 MGI
Cellular Component GO Annotation Evidence References Source
is active in Golgi membrane IDA
IDA: Inferred from direct assay
10759149 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
19841136 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11259273 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
18668520 MGI
located in cytosol IDA
IDA: Inferred from direct assay
18511518 MGI
located in female germ cell nucleus IDA
IDA: Inferred from direct assay
11259273 MGI
located in female pronucleus IDA
IDA: Inferred from direct assay
11259273 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
11172003 MGI
located in membrane IDA
IDA: Inferred from direct assay
11259273 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
18511518 MGI
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
25957687 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
36423686 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10394363 MGI
located in presynapse IDA
IDA: Inferred from direct assay
30335140 MGI
located in synapse IDA
IDA: Inferred from direct assay
29490264 MGI
located in vesicle IDA
IDA: Inferred from direct assay
11259273 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc2a1 Protein Structure

MFS_GLUT_Class1

MFS_GLUT_Class1: cd17431 (13 - 457)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 492 a.a.
Protein Preferred Names Protein Names

solute carrier family 2, facilitated glucose transporter member 1

  • GT1

  • glucose transporter type 1, erythrocyte/brain

  • solute carrier family 2, member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13157 SLC2A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13158 Slc2a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13159 Slc2a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180874 SLC2A1 modulator-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc2a1 NCBI NCBI:6513