Slc2a4 - solute carrier family 2 (facilitated glucose transporter), member 4 Gene

Also Known as GT2; twgy; Glut4; Glut-4

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20528

About Slc2a4

Chromosome 11: 69,833,365-69,839,014 reverse strand.GRCm39:CM001004.3

This gene has 8 transcripts (splice variants), 289 orthologues, 11 paralogues and is associated with 36 phenotypes. Biased expression in heart adult (RPKM 161.8), mammary gland adult (RPKM 97.3) and 12 other tissues.

Summary

Enables glucose transmembrane transporter activity. Involved in cellular response to Insulin stimulus. Acts upstream of or within several processes, including amylopectin biosynthetic process; brown fat cell differentiation; and glucose import in response to Insulin stimulus. Located in several cellular components, including cytoplasmic vesicle; extracellular exosome; and sarcolemma. Is integral component of plasma membrane. Is expressed in several structures, including adipose tissue; adrenal gland; alimentary system; brain; and genitourinary system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC2A4 (solute carrier family 2 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc2a4 Products (2)

mRNA	Protein	Name
NM_009204.2	NP_033230.2	solute carrier family 2, facilitated glucose transporter member 4 isoform 1
NM_001359114.1	NP_001346043.1	solute carrier family 2, facilitated glucose transporter member 4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	12097321	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16455755	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	12097321	MGI
acts upstream of or within amylopectin biosynthetic process	IDA IDA: Inferred from direct assay	14562105	MGI
acts upstream of or within brown fat cell differentiation	IDA IDA: Inferred from direct assay	18492766	MGI
acts upstream of or within cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	18227281	MGI
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	26240143	MGI
acts upstream of or within cellular response to osmotic stress	IDA IDA: Inferred from direct assay	18227281	MGI
acts upstream of or within cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	1618860	MGI
acts upstream of or within glucose import in response to insulin stimulus	IDA IDA: Inferred from direct assay	26629404	MGI
involved in glucose import in response to insulin stimulus	IDA IDA: Inferred from direct assay	26240143	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	12490950	MGI
located in cytosol	IDA IDA: Inferred from direct assay	18511518	MGI
located in endomembrane system	IDA IDA: Inferred from direct assay	21907143	MGI
located in endosome	IDA IDA: Inferred from direct assay	15247266	MGI
located in extracellular exosome	IDA IDA: Inferred from direct assay	19724054	MGI
located in insulin-responsive compartment	IDA IDA: Inferred from direct assay	12490950	MGI
located in membrane	IDA IDA: Inferred from direct assay	14562105	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	18511518	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10444069	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10394363	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	16455755	MGI
located in trans-Golgi network transport vesicle	IDA IDA: Inferred from direct assay	17003038	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc2a4 Protein Structure

MFS_GLUT_Class1

0
100
200
300
400
509 a.a.

Protein Preferred Names	Protein Names
solute carrier family 2, facilitated glucose transporter member 4	glucose transporter type 4, insulin-responsive

Slc2a4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Slc2a4	P14142	Esyt1	Mus musculus	Q3U7R1	Anti Bait CoIP	19255425

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13170	SLC2A4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13171	Slc2a4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13172	Slc2a4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13173	SLC2A4RG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc2a4	NCBI	NCBI:6517