SLC2A4 - solute carrier family 2 member 4 Gene

Also Known as GLUT4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6517

About SLC2A4

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,281,718-7,288,257 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 289 orthologues and 13 paralogues. Biased expression in heart (RPKM 32.2), fat (RPKM 24.5) and 6 other tissues.

Summary

This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of Insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of Insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]

SLC2A4 Products (1)

mRNA	Protein	Name
NM_001042.3	NP_001033.1	solute carrier family 2, facilitated glucose transporter member 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	25004245	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19478182	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	12556481	GOA
acts upstream of or within glucose homeostasis	IDA IDA: Inferred from direct assay	14562105	GOA
involved in glucose homeostasis	IDA IDA: Inferred from direct assay	17003346	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	19478182	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	14562105	GOA
located in insulin-responsive compartment	IDA IDA: Inferred from direct assay	19590752	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12556481	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	31112275	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12556481	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	12467732	GOA
located in vesicle membrane	IDA IDA: Inferred from direct assay	14562105	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC2A4 Protein Structure

Sugar_tr

0
100
200
300
400
509 a.a.

Protein Preferred Names	Protein Names
solute carrier family 2, facilitated glucose transporter member 4	GLUT-4 glucose transporter type 4, insulin-responsive insulin-responsive glucose transporter type 4 solute carrier family 2 (facilitated glucose transporter), member 4

SLC2A4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC2A4	P14672	CREB3	Homo sapiens	O43889-2	Validated Y2H	25910212
Intra	SLC2A4	P14672	CREB3	Homo sapiens	O43889-2	Y2H Array	25910212
Intra	SLC2A4	P14672	CREB3	Homo sapiens	O43889-2	Y2H Bait-Prey Pool	25910212

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC2A4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80495	Glucose Transporter GLUT4 Antibody (YA753)	WB, ICC/IF, IHC-P	Human, Mouse
HY-P80689	Glucose Transporter GLUT4 Antibody	WB, IHC-P, ELISA	Human, Mouse, Rat
HY-P810626	Phospho-Glucose Transporter GLUT4 (Ser488) Antibody (YA9888)	WB	Human, Mouse, Rat
HY-P84098	Glucose Transporter GLUT4 Antibody (YA3795)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P84098A	Glucose Transporter GLUT4 Antibody (YA3795)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P86894	Glucose Transporter GLUT4 Antibody (YA6587)	WB, IHC-F	Mouse, Rat

Related Diseases

Diseases	Alias
Glucose Metabolism Disease	Glucose Metabolism Disorders Disorder Of Glucose Metabolism
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Inherited Metabolic Disorder	Inborn Errors Of Metabolism Inborn Metabolism Disorder Metabolic Hereditary Disorder Inborn Error Of Metabolism Inborn Metabolic Disorder Metabolism, Inborn Errors
Liver Cirrhosis	Cirrhosis Cirrhosis Of Liver CIRRH Cryptogenic Cirrhosis Cirrhosis, Cryptogenic Cirrhosis Nos
Prediabetes Syndrome	Impaired Glucose Tolerance Prediabetes Prediabetic State IGT Igt - [Impaired Glucose Tolerance] Impaired Glucose Tolerance With Unspecified Complication Impaired Glucose Tolerance Without Complication Abnormal Glucose Tolerance
Abdominal Obesity-Metabolic Syndrome 1	Metabolic Syndrome X Metabolic Syndrome AOMS1 Dysmetabolic Syndrome X Metabolic Disease Abdominal Obesity Metabolic Syndrome
Diabetic Encephalopathy
Hyperinsulinism	Hyperinsulinemia
Acquired Metabolic Disease
Acanthosis Nigricans	Keratosis Nigricans An
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2	Abdominal Obesity-Metabolic Syndrome Abdominal Obesity Metabolic Syndrome Metabolic Syndrome X Aoms2 Aoms1
Myopathy	Muscular Diseases Myopathies
Overnutrition
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Diabetes Mellitus	Diabetes
Glucose Intolerance	Glucose: Intolerance Glucose: Malabsorption Malabsorption Of Glucose Impaired Glucose Tolerance
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Carbohydrate Metabolic Disorder	Inborn Errors Of Carbohydrate Metabolism Disorder Of Carbohydrate Metabolism Carbohydrate Metabolism, Inborn Errors Disorder Of Carbohydrate Transport And Metabolism Inborn Carbohydrate Metabolism Disorder Inborn Carbohydrate Metabolic Disorder Carbohydrate Metabolism Disorder Carbohydrate Metabolism Disorders Disorders Of Carbohydrate Metabolism Congenital Disorders Of Carbohydrate Metabolism Inherited Disorders Of Carbohydrate Metabolism
Gestational Diabetes	Gestational Diabetes Mellitus GDM Diabetes Mellitus Arising In Pregnancy Maternal Gestational Diabetes Mellitus Diabetes Mellitus, Gestational Diabetes Mellitus, Pregnancy Related Diabetes, Pregnancy-Induced Diabetes Gestational Diabetes, Gestational Diabetes Of Pregnancy Gdm - [Gestational Diabetes Mellitus] Gestational Diabetes Mellitus Nos Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction Leptin
Clear Cell Adenocarcinoma	Mesonephroma Water-Clear Cell Adenocarcinoma Adenocarcinoma, Clear Cell Malignant Mesonephroma Mesonephroid Clear Cell Carcinoma Mesonephroma, Malignant Water-Clear Cell Carcinoma Wolffian Duct Neoplasm Adenocarcinoma Clear Cell Mesonephric Tumor
Adult Syndrome	Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome Acro Dermato Ungual Lacrimal Tooth Syndrome Pigment Anomaly-Ectrodactyly-Hypodontia Syndrome Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome Adult
Polycystic Ovary Syndrome	Polycystic Ovarian Syndrome Pcos Polycystic Ovaries Stein-Leventhal Syndrome Multicystic Ovaries Polycystic Ovarian Disease Polycystic Ovary Sclerocystic Ovaries Sclerocystic Ovary Syndrome Stein-Leventhal Synd. Cystic Disease Of Ovaries Cystic Disease Of Ovary Pco Pcod Sclerocystic Ovarian Degeneration Polycystic Ovary Syndrome, Susceptibility To Pcos - [Polycystic Ovary Syndrome] Polycystic Ovary Nos Pco - [Polycystic Ovary]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13170	SLC2A4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13171	Slc2a4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13172	Slc2a4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13173	SLC2A4RG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC2A4	VGNC	VGNC:53442
Bos taurus	SLC2A4	VGNC	VGNC:34801
Rattus norvegicus	SLC2A4	RGD	RGD:2711
Macaca mulatta	SLC2A4	VGNC	VGNC:77449
Felis catus	SLC2A4	VGNC	VGNC:65303
Mus musculus	SLC2A4	MGD	MGI:95758
Others	SLC2A4	NCBI