Slc6a2 - solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Gene

Also Known as NET; NE-T; Slc6a5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20538

Summary

Enables monoamine transmembrane transporter activity and neurotransmitter transmembrane transporter activity. Involved in neurotransmitter reuptake and norepinephrine uptake. Acts upstream of or within neurotransmitter transport and response to pain. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection; neuronal cell body membrane; and presynaptic membrane. Predicted to be integral component of plasma membrane. Is expressed in adrenal gland; lip; nervous system; sensory organ; and testis. Used to study heart conduction disease. Human ortholog(s) of this gene implicated in hypertension and neurocirculatory asthenia. Orthologous to human SLC6A2 (solute carrier family 6 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a2 Products (1)

mRNA Protein Name
NM_009209.3 NP_033235.3 sodium-dependent noradrenaline transporter

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables monoamine transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
20858707 MGI
enables neurotransmitter transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
20858707 MGI
enables norepinephrine:sodium symporter activity IDA
IDA: Inferred from direct assay
16269905 MGI
Biological Process GO Annotation Evidence References Source
involved in neurotransmitter reuptake IDA
IDA: Inferred from direct assay
10769386 MGI
involved in neurotransmitter reuptake IMP
IMP: Inferred from mutant phenotype
10769386 MGI
acts upstream of or within neurotransmitter transport IDA
IDA: Inferred from direct assay
11805341 MGI
involved in neurotransmitter transport IMP
IMP: Inferred from mutant phenotype
20858707 MGI
involved in norepinephrine uptake IMP
IMP: Inferred from mutant phenotype
20858707 MGI
acts upstream of or within response to pain IMP
IMP: Inferred from mutant phenotype
11805341 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium-dependent noradrenaline transporter

  • NE transporter

  • norepinephrine transporter

  • solute carrier family 6 member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13306 SLC6A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20194 Slc6a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26699 Slc6a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a2 NCBI NCBI:6530