Slit1 - slit guidance ligand 1 Gene

Also Known as Slil1; mKIAA0813

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20562

Summary

Enables Roundabout binding activity. Acts upstream of or within several processes, including axon guidance; nuclear migration; and tangential migration from the subventricular zone to the olfactory bulb. Located in extracellular space. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; olfactory system; and retina. Orthologous to human SLIT1 (slit guidance ligand 1). [provided by Alliance of Genome Resources, Apr 2022]

Slit1 Products (1)

mRNA Protein Name
NM_015748.3 NP_056563.2 slit homolog 1 protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Roundabout binding IPI
IPI: Inferred from physical interaction
10433822 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
12954717 MGI
acts upstream of or within axon guidance IGI
IGI: Inferred from genetic interaction
11804571 MGI
acts upstream of or within axonogenesis IDA
IDA: Inferred from direct assay
12097499 MGI
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
12097499 MGI
acts upstream of or within dorsal/ventral axon guidance IGI
IGI: Inferred from genetic interaction
11804571 MGI
acts upstream of or within negative chemotaxis IMP
IMP: Inferred from mutant phenotype
12097499 MGI
acts upstream of or within neuron projection morphogenesis IGI
IGI: Inferred from genetic interaction
11804571 MGI
acts upstream of or within nuclear migration IDA
IDA: Inferred from direct assay
12051827 MGI
acts upstream of or within olfactory bulb development IGI
IGI: Inferred from genetic interaction
12097499 MGI
acts upstream of or within retinal ganglion cell axon guidance IGI
IGI: Inferred from genetic interaction
11804570 MGI
acts upstream of or within retinal ganglion cell axon guidance IMP
IMP: Inferred from mutant phenotype
16828733 MGI
acts upstream of or within tangential migration from the subventricular zone to the olfactory bulb IMP
IMP: Inferred from mutant phenotype
14960623 MGI
acts upstream of or within telencephalon cell migration IGI
IGI: Inferred from genetic interaction
14960623 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
12954717 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

slit homolog 1 protein

  • slit-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13370 SLIT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13372 SLIT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20490 Slit3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21757 Slit1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28275 Slit1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slit1 NCBI NCBI:6585