SLIT1 - slit guidance ligand 1 Gene

Also Known as MEGF4; SLIL1; SLIT3; SLIT-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6585

About SLIT1

Cytogenetic location: 10q24.1 Genomic coordinates (GRCh38): 10:96,998,038-97,185,959 (from NCBI)

This gene has 7 transcripts (splice variants), 255 orthologues and 25 paralogues. Biased expression in brain (RPKM 15.8) and thyroid (RPKM 1.3).

Summary

Enables Roundabout binding activity. Involved in axon extension involved in axon guidance; motor neuron axon guidance; and negative chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SLIT1 Products (1)

mRNA Protein Name
NM_003061.3 NP_003052.2 slit homolog 1 protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables Roundabout binding IPI
IPI: Inferred from physical interaction
15207848 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21653829 GOA
Biological Process GO Annotation Evidence References Source
involved in axon extension involved in axon guidance IDA
IDA: Inferred from direct assay
16840550 GOA
involved in axon guidance IDA
IDA: Inferred from direct assay
11748139 GOA
NOT involved in chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration IDA
IDA: Inferred from direct assay
11748139 GOA
involved in motor neuron axon guidance IMP
IMP: Inferred from mutant phenotype
16162649 GOA
involved in negative chemotaxis IDA
IDA: Inferred from direct assay
11748139 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLIT1 Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (33 - 60)

LRR_8

LRR_8: Leucine rich repeat (62 - 121)

LRR_8

LRR_8: Leucine rich repeat (159 - 217)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (239 - 264)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (282 - 308)

LRR_8

LRR_8: Leucine rich repeat (334 - 393)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (464 - 488)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (513 - 539)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (544 - 581)

LRR_8

LRR_8: Leucine rich repeat (590 - 649)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (695 - 720)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (733 - 760)

LRR_8

LRR_8: Leucine rich repeat (786 - 844)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (891 - 915)

EGF

EGF: EGF-like domain (929 - 959)

EGF

EGF: EGF-like domain (1047 - 1079)

EGF

EGF: EGF-like domain (1087 - 1116)

Laminin_G_2

Laminin_G_2: Laminin G domain (1195 - 1322)

hEGF

hEGF: Human growth factor-like EGF (1400 - 1412)

hEGF

hEGF: Human growth factor-like EGF (1442 - 1453)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1534 a.a.
Protein Preferred Names Protein Names

slit homolog 1 protein

  • multiple EGF-like domains protein 4

SLIT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLIT1 O75093 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
SLIT1 O75093 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
SLIT1 O75093 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
SLIT1 O75093 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
SLIT1 O75093 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
SLIT1 O75093 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
32296183
Intra
SLIT1 O75093 KRTAP13-3 Homo sapiens Q3SY46
Y2H Array
32296183
Intra
SLIT1 O75093 KRTAP13-3 Homo sapiens Q3SY46
Y2H Prey Pooling
32296183
Intra
SLIT1 O75093 KRTAP13-3 Homo sapiens Q3SY46
Validated Y2H
32296183
Intra
SLIT1 O75093 KRTAP13-2 Homo sapiens Q52LG2
Y2H Prey Pooling
32296183
Intra
SLIT1 O75093 KRTAP13-2 Homo sapiens Q52LG2
Y2H Array
32296183
Intra
SLIT1 O75093 KRTAP13-2 Homo sapiens Q52LG2
Validated Y2H
32296183
Intra
SLIT1 O75093 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
SLIT1 O75093 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
SLIT1 O75093 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
SLIT1 O75093 CHRDL2 Homo sapiens Q6WN34-2
Y2H Prey Pooling
32296183
Intra
SLIT1 O75093 CHRDL2 Homo sapiens Q6WN34-2
Validated Y2H
32296183
Intra
SLIT1 O75093 CHRDL2 Homo sapiens Q6WN34-2
Y2H Array
32296183
Intra
SLIT1 O75093 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
SLIT1 O75093 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
SLIT1 O75093 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
SLIT1 O75093 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
SLIT1 O75093 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
SLIT1 O75093 ZNF620 Homo sapiens Q6ZNG0
Validated Y2H
32296183
Intra
SLIT1 O75093 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra
SLIT1 O75093 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra
SLIT1 O75093 TRIM42 Homo sapiens Q8IWZ5
Validated Y2H
32296183
Intra
SLIT1 O75093 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
32296183
Intra
SLIT1 O75093 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
32296183
Intra
SLIT1 O75093 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
SLIT1 O75093 HOXA1 Homo sapiens P49639
Validated Y2H
32296183
Intra
SLIT1 O75093 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
SLIT1 O75093 HOXA1 Homo sapiens P49639
Y2H Pooling
21653829
Intra
SLIT1 O75093 FHL5 Homo sapiens Q5TD97
Validated Y2H
32296183
Intra
SLIT1 O75093 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra
SLIT1 O75093 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatic Adenomas, Familial

  • Hepatic Adenoma, Somatic

  • Familial Hepatic Adenoma

  • Familial Liver Cell Adenomas

  • Liver Cell Adenomas, Familial

  • Hepatic Adenomas Familial

  • HEPAF

  • Ha

  • Hepatocellular Adenomas

  • Hepatocellular Adenoma
Diaphragm Disease

  • Abnormality Of The Diaphragm

  • Disease Of Diaphragm

  • Diaphragmatic Disorder

  • Disorder Of Diaphragm
Diaphragmatic Hernia, Congenital

  • Congenital Diaphragmatic Hernia

  • Diaphragmatic Hernia

  • Cdh

  • Congenital Diaphragmatic Defect

  • Hernia, Diaphragmatic

  • Dih

  • Hernia, Congenital Diaphragmatic

  • Hcd

  • Diaphragmatic Defect, Congenital

  • Diaphragm, Unilateral Agenesis Of

  • Hemidiaphragm, Agenesis Of

  • Diaphragmatic Hernia 1

  • Agenesis Of Hemidiaphragm

  • Unilateral Agenesis Of Diaphragm

  • Hernia Diaphragmatic

  • Hernia Diaphragmatic Congenital

  • Hernia, Diaphragmatic, Type 1

  • Hiatus Hernia

  • Oesophageal Hiatus Hernia

  • Paraoesophageal Hernia

  • Sliding Hiatus Hernia

  • Congenital Diaphragm Hernia

  • Congenital Diaphragm Defect With Hernia

  • Gross Congenital Diaphragm Defect
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13370 SLIT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13372 SLIT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20490 Slit3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21757 Slit1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28275 Slit1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SLIT1 VGNC VGNC:55971
Felis catus SLIT1 VGNC VGNC:107071
Rattus norvegicus SLIT1 RGD RGD:69307
Macaca mulatta SLIT1 VGNC VGNC:77643
Canis familiaris SLIT1 VGNC VGNC:53014
Mus musculus SLIT1 MGD MGI:1315203
Others SLIT1 NCBI