2. Gene
  3. SLIT1 - slit guidance ligand 1 Gene

SLIT1 - slit guidance ligand 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MEGF4; SLIL1; SLIT3; SLIT-1

Gene ID: 6585 | Gene type: protein coding

About SLIT1

Cytogenetic location: 10q24.1 Genomic coordinates (GRCh38): 10:96,998,038-97,185,959 (from NCBI)

This gene has 7 transcripts (splice variants), 255 orthologues and 25 paralogues. Biased expression in brain (RPKM 15.8) and thyroid (RPKM 1.3).

Summary

Enables Roundabout binding activity. Involved in axon extension involved in axon guidance; motor neuron axon guidance; and negative chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SLIT1 Products(1)

mRNA Protein Name
NM_003061.3 NP_003052.2 slit homolog 1 protein precursor

SLIT1 Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (33 - 60)

LRR_8

LRR_8: Leucine rich repeat (62 - 121)

LRR_8

LRR_8: Leucine rich repeat (159 - 217)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (239 - 264)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (282 - 308)

LRR_8

LRR_8: Leucine rich repeat (334 - 393)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (464 - 488)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (513 - 539)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (544 - 581)

LRR_8

LRR_8: Leucine rich repeat (590 - 649)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (695 - 720)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (733 - 760)

LRR_8

LRR_8: Leucine rich repeat (786 - 844)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (891 - 915)

EGF

EGF: EGF-like domain (929 - 959)

EGF

EGF: EGF-like domain (1047 - 1079)

EGF

EGF: EGF-like domain (1087 - 1116)

Laminin_G_2

Laminin_G_2: Laminin G domain (1195 - 1322)

hEGF

hEGF: Human growth factor-like EGF (1400 - 1412)

hEGF

hEGF: Human growth factor-like EGF (1442 - 1453)

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  • 1534 a.a.
Protein Preferred Names Protein Names

slit homolog 1 protein

multiple EGF-like domains protein 4

Recombinant SLIT1 Proteins

Cat. No. Product Name Accession Purity
HY-P79427 Slit1 Protein, Human (HEK293, His) O75093-1 (S1129-A1534 ) ≥95%

Related Diseases

Diseases Alias
Hepatic Adenomas, Familial

Hepatic Adenoma, Somatic

Familial Hepatic Adenoma

Familial Liver Cell Adenomas

Liver Cell Adenomas, Familial

Hepatic Adenomas Familial

HEPAF

Ha

Hepatocellular Adenomas

Hepatocellular Adenoma
Diaphragm Disease

Abnormality Of The Diaphragm

Disease Of Diaphragm

Diaphragmatic Disorder

Disorder Of Diaphragm
Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia

Diaphragmatic Hernia

Cdh

Congenital Diaphragmatic Defect

Hernia, Diaphragmatic

Dih

Hernia, Congenital Diaphragmatic

Hcd

Diaphragmatic Defect, Congenital

Diaphragm, Unilateral Agenesis Of

Hemidiaphragm, Agenesis Of

Diaphragmatic Hernia 1

Agenesis Of Hemidiaphragm

Unilateral Agenesis Of Diaphragm

Hernia Diaphragmatic

Hernia Diaphragmatic Congenital

Hernia, Diaphragmatic, Type 1

Hiatus Hernia

Oesophageal Hiatus Hernia

Paraoesophageal Hernia

Sliding Hiatus Hernia

Congenital Diaphragm Hernia

Congenital Diaphragm Defect With Hernia

Gross Congenital Diaphragm Defect
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13370 SLIT1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SLIT1 VGNC VGNC:55971
Felis catus SLIT1 VGNC VGNC:107071
Rattus norvegicus SLIT1 RGD RGD:69307
Macaca mulatta SLIT1 VGNC VGNC:77643
Canis familiaris SLIT1 VGNC VGNC:53014
Mus musculus SLIT1 MGD MGI:1315203