Kdm5c - lysine (K)-specific demethylase 5C Gene

Also Known as Smcx; Jarid1c; mKIAA0234; D930009K15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20591

Summary

Predicted to enable several functions, including histone H3-tri/di/monomethyl-lysine-4 demethylase activity; identical protein binding activity; and zinc ion binding activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within histone H3-K4 demethylation. Located in nucleus. Is expressed in several structures, including brain; early conceptus; gonad; limb; and metanephros. Used to study syndromic X-linked intellectual disability Claes-Jensen type. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Claes-Jensen type. Orthologous to human KDM5C (lysine demethylase 5C). [provided by Alliance of Genome Resources, Apr 2022]

Kdm5c Products (7)

mRNA Protein Name
NM_001403071.1 NP_001390000.1 lysine-specific demethylase 5C isoform 2
NM_001403072.1 NP_001390001.1 lysine-specific demethylase 5C isoform 3
NM_001403073.1 NP_001390002.1 lysine-specific demethylase 5C isoform 4
NM_001403074.1 NP_001390003.1 lysine-specific demethylase 5C isoform 5
NM_001403075.1 NP_001390004.1 lysine-specific demethylase 5C isoform 6
NM_001403076.1 NP_001390005.1 lysine-specific demethylase 5C isoform 7
NM_013668.5 NP_038696.2 lysine-specific demethylase 5C isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H3K4 demethylase activity IDA
IDA: Inferred from direct assay
23246292 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
21960634 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
23246292 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific demethylase 5C

  • [histone H3]-trimethyl-L-lysine(4) demethylase 5C

  • histone demethylase JARID1C

  • jumonji, AT rich interactive domain 1C (Rbp2 like)

  • jumonji/ARID domain-containing protein 1C

  • selected mouse cDNA on the X

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120400 KDM5-C70 Inhibitor 98.82% Unkown
HY-102047B KDOAM-25 citrate Inhibitor 98.56% Unkown
HY-100014 KDM5A-IN-1 Inhibitor 99.64% Unkown
HY-119397A KDM5-C49 hydrochloride Inhibitor 98.22% Unkown
HY-158432 GT-653 Degrader 99.84% Unkown
HY-100764 YUKA1 Inhibitor 99.15% Unkown
HY-102047 KDOAM-25 Inhibitor / Unkown
HY-119397 KDM5-C49 Inhibitor / Unkown
HY-RS07220 KDM5C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-102047A KDOAM-25 trihydrochloride Inhibitor / Unkown
HY-183618 DW-229 Degrader / Unkown
HY-RS16858 Kdm5c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23299 Kdm5c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm5c NCBI NCBI:8242