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Sox17 - SRY (sex determining region Y)-box 17 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20671

Summary

This gene encodes a member of the Sox (Sry-related high mobility group box) family of transcription factors involved in the regulation of embryonic development. The encoded protein plays a role in the determination of cell fate and in maintaining cell identity. This gene regulates tumor angiogenesis and tumor progression. Mutations in the human gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Sox17 Products (5)

mRNA	Protein	Name
NM_001289464.1	NP_001276393.1	transcription factor SOX-17 isoform a
NM_001289465.1	NP_001276394.1	transcription factor SOX-17 isoform b
NM_001289466.1	NP_001276395.1	transcription factor SOX-17 isoform b
NM_001289467.1	NP_001276396.1	transcription factor SOX-17 isoform c
NM_011441.5	NP_035571.1	transcription factor SOX-17 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15082719	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8636240	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	17360443	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19515696	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15220343	MGI
enables beta-catenin binding	IDA IDA: Inferred from direct assay	17360443	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17875931	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8636240	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	8636240	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within angiogenesis	IGI IGI: Inferred from genetic interaction	16895970	MGI
involved in cardiogenic plate morphogenesis	IMP IMP: Inferred from mutant phenotype	21305474	MGI
acts upstream of or within cell migration involved in gastrulation	IMP IMP: Inferred from mutant phenotype	21146513	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IDA IDA: Inferred from direct assay	20439489	MGI
acts upstream of or within common bile duct development	IMP IMP: Inferred from mutant phenotype	19913509	MGI
acts upstream of or within embryonic foregut morphogenesis	IMP IMP: Inferred from mutant phenotype	18462699	MGI
involved in embryonic foregut morphogenesis	IMP IMP: Inferred from mutant phenotype	21305474	MGI
acts upstream of or within embryonic heart tube development	IGI IGI: Inferred from genetic interaction	17610846	MGI
involved in embryonic heart tube morphogenesis	IMP IMP: Inferred from mutant phenotype	21305474	MGI
acts upstream of or within embryonic organ development	IMP IMP: Inferred from mutant phenotype	19913509	MGI
acts upstream of or within endocardial cell differentiation	IGI IGI: Inferred from genetic interaction	17610846	MGI
acts upstream of or within endocardium formation	IGI IGI: Inferred from genetic interaction	17610846	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	19913509	MGI
involved in endoderm development	IMP IMP: Inferred from mutant phenotype	11973269	MGI
acts upstream of endodermal cell differentiation	IDA IDA: Inferred from direct assay	17940068	MGI
acts upstream of or within endodermal cell fate determination	IDA IDA: Inferred from direct assay	20308546	MGI
involved in endodermal cell fate specification	IMP IMP: Inferred from mutant phenotype	21305474	MGI
involved in endodermal digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	21305474	MGI
acts upstream of or within gallbladder development	IMP IMP: Inferred from mutant phenotype	19913509	MGI
acts upstream of or within gastrulation	IMP IMP: Inferred from mutant phenotype	20123909	MGI
acts upstream of gene expression	IMP IMP: Inferred from mutant phenotype	17940068	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	17360443	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	17610846	MGI
involved in heart looping	IMP IMP: Inferred from mutant phenotype	17610846	MGI
acts upstream of or within inner cell mass cellular morphogenesis	IMP IMP: Inferred from mutant phenotype	21146513	MGI
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	20802155	MGI
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17360443	MGI
involved in outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	17610846	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15220343	MGI
acts upstream of or within positive regulation of endodermal cell differentiation	IDA IDA: Inferred from direct assay	17940068	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17940068	MGI
involved in positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	20802155	MGI
acts upstream of or within positive regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	20123909	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8636240	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17360443	MGI
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20802155	MGI
involved in regulation of cardiac cell fate specification	IMP IMP: Inferred from mutant phenotype	17360443	MGI
acts upstream of or within regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	21146513	MGI
involved in regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	11973269	MGI
acts upstream of or within regulation of stem cell division	IMP IMP: Inferred from mutant phenotype	20123909	MGI
acts upstream of or within regulation of stem cell proliferation	IDA IDA: Inferred from direct assay	20228271	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21305474	MGI
acts upstream of or within rostrocaudal neural tube patterning	IMP IMP: Inferred from mutant phenotype	19913509	MGI
acts upstream of or within signal transduction involved in regulation of gene expression	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within spermatogenesis	IDA IDA: Inferred from direct assay	8636240	MGI
acts upstream of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	20123909	MGI
acts upstream of or within stem cell differentiation	IMP IMP: Inferred from mutant phenotype	20123909	MGI
acts upstream of or within stem cell fate specification	IDA IDA: Inferred from direct assay	20228271	MGI
acts upstream of or within vasculogenesis	IGI IGI: Inferred from genetic interaction	16895970	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	8636240	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	22344693	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor SOX-17	SRY-box containing gene 17

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116940	Sm4	Inhibitor	99.01%	Unkown
HY-161024	AC1Q3QWB	Inhibitor	99.76%	Unkown
HY-RS20493	Sox17 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13589	SOX17 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27001	Sox17 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sox17	NCBI	NCBI:64321