Sox18 - SRY (sex determining region Y)-box 18 Gene

Also Known as Ra; Ragl

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20672

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including circulatory system development; regulation of transcription, DNA-templated; and stem cell fate specification. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; immune system; reproductive system; and urinary system. Human ortholog(s) of this gene implicated in hypotrichosis-lymphedema-telangiectasia syndrome and hypotrichosis-lymphedema-telangiectasia-renal defect syndrome. Orthologous to human SOX18 (SRY-box transcription factor 18). [provided by Alliance of Genome Resources, Apr 2022]

Sox18 Products (1)

mRNA Protein Name
NM_009236.2 NP_033262.2 transcription factor SOX-18

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12446692 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
7651823 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
22344693 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11554755 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7651823 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
14634005 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IGI
IGI: Inferred from genetic interaction
16895970 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
10742113 MGI
acts upstream of or within cell maturation IDA
IDA: Inferred from direct assay
20228271 MGI
acts upstream of or within embryonic heart tube development IGI
IGI: Inferred from genetic interaction
17610846 MGI
acts upstream of or within endocardial cell differentiation IGI
IGI: Inferred from genetic interaction
17610846 MGI
acts upstream of or within endocardium formation IGI
IGI: Inferred from genetic interaction
17610846 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
10742113 MGI
NOT acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
11094083 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
10742113 MGI
NOT acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
11094083 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
10742113 MGI
acts upstream of or within lymph vessel development IMP
IMP: Inferred from mutant phenotype
291594 MGI
acts upstream of or within lymphangiogenesis IMP
IMP: Inferred from mutant phenotype
18931657 MGI
acts upstream of or within lymphatic endothelial cell differentiation IMP
IMP: Inferred from mutant phenotype
18931657 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18931657 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
7651823 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11554755 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12446692 MGI
acts upstream of or within regulation of stem cell proliferation IDA
IDA: Inferred from direct assay
20228271 MGI
acts upstream of or within stem cell fate specification IDA
IDA: Inferred from direct assay
20228271 MGI
acts upstream of or within vasculature development IMP
IMP: Inferred from mutant phenotype
19429912 MGI
acts upstream of or within vasculogenesis IGI
IGI: Inferred from genetic interaction
16895970 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11554755 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
22344693 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor SOX-18

  • SRY-box containing gene 18

  • Sry-related HMG-box gene 18

  • ragged

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116940 Sm4 Inhibitor 99.01% Unkown
HY-RS20494 Sox18 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13590 SOX18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27002 Sox18 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sox18 NCBI NCBI:54345