Sp3 - trans-acting transcription factor 3 Gene

Also Known as D130027J01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20687

Summary

This gene product belongs to a family of Sp1 related transcription factors, which regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses transcription of numerous genes. Alternative splicing results in transcript variants encoding different isoforms, and one variant initiates translation from a non-AUG (AUA) codon. [provided by RefSeq, Jul 2008]

Sp3 Products (2)

mRNA Protein Name
NM_001018042.3 NP_001018052.1 transcription factor Sp3 isoform 1
NM_001098425.1 NP_001091895.1 transcription factor Sp3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
14630713 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17130167 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15094381 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
17130167 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
15522233 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15511642 MGI
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
15282343 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20385708 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell differentiation IMP
IMP: Inferred from mutant phenotype
12676787 MGI
acts upstream of or within T cell differentiation IMP
IMP: Inferred from mutant phenotype
12676787 MGI
acts upstream of or within definitive hemopoiesis IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within embryonic camera-type eye morphogenesis IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within embryonic placenta development IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within embryonic process involved in female pregnancy IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within embryonic skeletal system development IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within enucleate erythrocyte differentiation IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
12676787 MGI
acts upstream of or within granulocyte differentiation IMP
IMP: Inferred from mutant phenotype
12676787 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within liver development IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within lung development IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within megakaryocyte differentiation IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within monocyte differentiation IMP
IMP: Inferred from mutant phenotype
12676787 MGI
acts upstream of or within myeloid progenitor cell differentiation IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within natural killer cell differentiation IMP
IMP: Inferred from mutant phenotype
12676787 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17130167 MGI
acts upstream of or within ossification IGI
IGI: Inferred from genetic interaction
17584888 MGI
acts upstream of or within trophectodermal cell differentiation IGI
IGI: Inferred from genetic interaction
17584888 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15282343 MGI
part of transcription repressor complex IDA
IDA: Inferred from direct assay
17130167 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor Sp3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161794A SP3N hydrochloride Degrader 99.84% Unkown
HY-161795 SP3CHO 87.50% Unkown
HY-161794 SP3N Degrader / Unkown
HY-RS13606 SP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123732 CRT0083914 / Unkown
HY-173132 AKR1Cs-IN-1 / Unkown
HY-180813 RORγ-IN-3 Inhibitor / Unkown
HY-RS18594 Sp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25079 Sp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sp3 NCBI NCBI:6670