Srpk2 - serine/arginine-rich protein specific kinase 2 Gene
Also Known as Wbp6; mSRPK2
Species: Mus musculus
Gene Type: protein coding
Gene ID: 20817
Summary
Enables several functions, including 14-3-3 protein binding activity; ATP binding activity; and magnesium ion binding activity. Involved in several processes, including nuclear speck organization; positive regulation of neuron apoptotic process; and spliceosomal complex assembly. Located in cytoplasm and nucleus. Is expressed in central nervous system; neural retina; and olfactory epithelium. Orthologous to human SRPK2 (SRSF protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Srpk2 Products (32)
| mRNA | Protein | Name |
|---|---|---|
| NM_001359172.2 | NP_001346101.1 | SRSF protein kinase 2 isoform a |
| NM_001359173.2 | NP_001346102.1 | SRSF protein kinase 2 isoform b |
| NM_001359174.2 | NP_001346103.1 | SRSF protein kinase 2 isoform c |
| NM_001359175.2 | NP_001346104.1 | SRSF protein kinase 2 isoform d |
| NM_001407496.1 | NP_001394425.1 | SRSF protein kinase 2 isoform f |
| NM_001407498.1 | NP_001394427.1 | SRSF protein kinase 2 isoform g |
| NM_001407499.1 | NP_001394428.1 | SRSF protein kinase 2 isoform h |
| NM_001407500.1 | NP_001394429.1 | SRSF protein kinase 2 isoform i |
| NM_001407501.1 | NP_001394430.1 | SRSF protein kinase 2 isoform j |
| NM_001407502.1 | NP_001394431.1 | SRSF protein kinase 2 isoform k |
| NM_001407503.1 | NP_001394432.1 | SRSF protein kinase 2 isoform l |
| NM_001407504.1 | NP_001394433.1 | SRSF protein kinase 2 isoform m |
| NM_001407505.1 | NP_001394434.1 | SRSF protein kinase 2 isoform c |
| NM_001407506.1 | NP_001394435.1 | SRSF protein kinase 2 isoform n |
| NM_001407507.1 | NP_001394436.1 | SRSF protein kinase 2 isoform d |
| NM_001407508.1 | NP_001394437.1 | SRSF protein kinase 2 isoform d |
| NM_001407509.1 | NP_001394438.1 | SRSF protein kinase 2 isoform d |
| NM_001407510.1 | NP_001394439.1 | SRSF protein kinase 2 isoform o |
| NM_001407511.1 | NP_001394440.1 | SRSF protein kinase 2 isoform p |
| NM_001407512.1 | NP_001394441.1 | SRSF protein kinase 2 isoform p |
| NM_001407513.1 | NP_001394442.1 | SRSF protein kinase 2 isoform q |
| NM_001407514.1 | NP_001394443.1 | SRSF protein kinase 2 isoform r |
| NM_001407515.1 | NP_001394444.1 | SRSF protein kinase 2 isoform s |
| NM_001407516.1 | NP_001394445.1 | SRSF protein kinase 2 isoform t |
| NM_001407517.1 | NP_001394446.1 | SRSF protein kinase 2 isoform u |
| NM_001407518.1 | NP_001394447.1 | SRSF protein kinase 2 isoform v |
| NM_001407519.1 | NP_001394448.1 | SRSF protein kinase 2 isoform w |
| NM_001407520.1 | NP_001394449.1 | SRSF protein kinase 2 isoform w |
| NM_001407521.1 | NP_001394450.1 | SRSF protein kinase 2 isoform x |
| NM_001407522.1 | NP_001394451.1 | SRSF protein kinase 2 isoform x |
| NM_001407523.1 | NP_001394452.1 | SRSF protein kinase 2 isoform y |
| NM_009274.3 | NP_033300.2 | SRSF protein kinase 2 isoform c |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables 14-3-3 protein binding |
IDA
IDA: Inferred from direct assay
|
19592491 | MGI |
| enables ATP binding |
IDA
IDA: Inferred from direct assay
|
9446799 | MGI |
| enables magnesium ion binding |
IDA
IDA: Inferred from direct assay
|
9446799 | MGI |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10196197 | MGI |
| enables protein serine/threonine kinase activity |
IDA
IDA: Inferred from direct assay
|
9446799 | MGI |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in RNA splicing |
IDA
IDA: Inferred from direct assay
|
9446799 | MGI |
| involved in angiogenesis |
IDA
IDA: Inferred from direct assay
|
19906640 | MGI |
| involved in intracellular signal transduction |
IDA
IDA: Inferred from direct assay
|
9446799 | MGI |
| involved in nuclear speck organization |
IDA
IDA: Inferred from direct assay
|
9446799 | MGI |
| involved in positive regulation of cell cycle |
IDA
IDA: Inferred from direct assay
|
19592491 | MGI |
| involved in positive regulation of cell population proliferation |
IDA
IDA: Inferred from direct assay
|
19592491 | MGI |
| involved in positive regulation of gene expression |
IDA
IDA: Inferred from direct assay
|
19592491 | MGI |
| involved in positive regulation of neuron apoptotic process |
IDA
IDA: Inferred from direct assay
|
19592491 | MGI |
| involved in protein phosphorylation |
IDA
IDA: Inferred from direct assay
|
9446799 | MGI |
| involved in spliceosomal complex assembly |
IDA
IDA: Inferred from direct assay
|
9446799 | MGI |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
9446799 | MGI |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
9446799 | MGI |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
SRSF protein kinase 2 |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(6)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-148518 | MSC-1186 | Inhibitor | 98.95% | Unkown |
| HY-113831 | CLK1/2-IN-3 | Inhibitor | / | Unkown |
| HY-E70805 | Biotin-SRPK2 Recombinant Human Active Protein Kinase | / | Unkown | |
| HY-RS13778 | SRPK2 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS18547 | Srpk2 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS25029 | Srpk2 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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