Stx3 - syntaxin 3 Gene

Also Known as Syn-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20908

Summary

Predicted to enable SNAP receptor activity; SNARE binding activity; and arachidonic acid binding activity. Involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane and vesicle-mediated transport in synapse. Acts upstream of or within exocytosis; long-term synaptic potentiation; and vesicle fusion. Located in several cellular components, including Schaffer collateral - CA1 synapse; cytoplasmic vesicle; and photoreceptor cell terminal bouton. Part of SNARE complex. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human STX3 (syntaxin 3). [provided by Alliance of Genome Resources, Apr 2022]

Stx3 Products (5)

mRNA Protein Name
NM_001025307.2 NP_001020478.1 syntaxin-3 isoform B
NM_001286543.2 NP_001273472.1 syntaxin-3 isoform D
NM_001360386.1 NP_001347315.1 syntaxin-3 isoform D
NM_011502.4 NP_035632.1 syntaxin-3 isoform C
NM_152220.2 NP_689344.1 syntaxin-3 isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8774707 MGI
Biological Process GO Annotation Evidence References Source
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane EXP
EXP: Inferred from Experiment
23395379 MGI
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IDA
IDA: Inferred from direct assay
23395379 MGI
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IEP
IEP: Inferred from expression pattern
23395379 MGI
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IMP
IMP: Inferred from mutant phenotype
23395379 MGI
acts upstream of or within exocytosis IMP
IMP: Inferred from mutant phenotype
18505797 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
23395379 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
23395379 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
23395379 MGI
involved in vesicle-mediated transport in synapse EXP
EXP: Inferred from Experiment
23395379 MGI
involved in vesicle-mediated transport in synapse IDA
IDA: Inferred from direct assay
23395379 MGI
involved in vesicle-mediated transport in synapse IEP
IEP: Inferred from expression pattern
23395379 MGI
involved in vesicle-mediated transport in synapse IMP
IMP: Inferred from mutant phenotype
23395379 MGI
Cellular Component GO Annotation Evidence References Source
part of SNARE complex IDA
IDA: Inferred from direct assay
18535671 MGI
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
23395379 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
23395379 MGI
is active in Schaffer collateral - CA1 synapse IEP
IEP: Inferred from expression pattern
23395379 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
23395379 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
10469351 MGI
located in dendrite IDA
IDA: Inferred from direct assay
23395379 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
23395379 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23395379 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
23395379 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23395379 MGI
located in melanosome IDA
IDA: Inferred from direct assay
23549422 MGI
located in membrane IDA
IDA: Inferred from direct assay
23395379 MGI
located in photoreceptor inner segment IMP
IMP: Inferred from mutant phenotype
33974130 MGI
located in photoreceptor outer segment IMP
IMP: Inferred from mutant phenotype
33974130 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
23395379 MGI
located in secretory granule IDA
IDA: Inferred from direct assay
18321981 MGI
located in zymogen granule membrane IDA
IDA: Inferred from direct assay
18535671 MGI
is active in zymogen granule membrane IPI
IPI: Inferred from physical interaction
18535671 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

syntaxin-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13983 STX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21438 Stx3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27956 Stx3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stx3 NCBI NCBI:6809