Stxbp1 - syntaxin binding protein 1 Gene

Also Known as Ms10g; nsec1; N-sec1; Sxtbp1; Unc18h; MMS10-G; Rb-sec1; Unc18-1; Munc-18a; Munc18-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20910

Summary

Enables syntaxin-1 binding activity. Involved in presynaptic dense core vesicle exocytosis and synaptic vesicle priming. Acts upstream of or within several processes, including axon target recognition; chemical synaptic transmission; and negative regulation of synaptic transmission. Located in several cellular components, including glutamatergic synapse; phagocytic vesicle; and presynaptic active zone membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in West syndrome and developmental and epileptic encephalopathy 4. Orthologous to human STXBP1 (syntaxin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Stxbp1 Products (2)

mRNA Protein Name
NM_001113569.1 NP_001107041.1 syntaxin-binding protein 1 isoform a
NM_009295.2 NP_033321.2 syntaxin-binding protein 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7598732 MGI
enables syntaxin-1 binding IDA
IDA: Inferred from direct assay
18703708 MGI
enables syntaxin-1 binding IPI
IPI: Inferred from physical interaction
7890599 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon target recognition IMP
IMP: Inferred from mutant phenotype
15182301 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
19144319 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
11545717 MGI
acts upstream of or within exocytosis IMP
IMP: Inferred from mutant phenotype
11545717 MGI
acts upstream of or within long-term synaptic depression IMP
IMP: Inferred from mutant phenotype
17110441 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
15255974 MGI
acts upstream of or within negative regulation of synaptic transmission, GABAergic IDA
IDA: Inferred from direct assay
17167098 MGI
acts upstream of or within neuromuscular synaptic transmission IMP
IMP: Inferred from mutant phenotype
17110441 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
15255974 MGI
acts upstream of or within neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
15255974 MGI
acts upstream of or within positive regulation of calcium ion-dependent exocytosis IDA
IDA: Inferred from direct assay
15123626 MGI
acts upstream of or within synaptic vesicle maturation IMP
IMP: Inferred from mutant phenotype
15145078 MGI
involved in synaptic vesicle priming IDA
IDA: Inferred from direct assay
17110441 MGI
involved in synaptic vesicle priming IMP
IMP: Inferred from mutant phenotype
17110441 MGI
acts upstream of or within vesicle docking involved in exocytosis IMP
IMP: Inferred from mutant phenotype
11545717 MGI
involved in vesicle docking involved in exocytosis IMP
IMP: Inferred from mutant phenotype
18703708 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
23821748 MGI
is active in extrinsic component of presynaptic membrane IDA
IDA: Inferred from direct assay
24590174 MGI
is active in extrinsic component of presynaptic membrane IMP
IMP: Inferred from mutant phenotype
24590174 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17110441 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17110441 MGI
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
32494600 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
19144319 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
23821748 MGI
is active in presynaptic active zone cytoplasmic component IDA
IDA: Inferred from direct assay
32494600 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
24590174 MGI
is active in presynaptic cytosol IMP
IMP: Inferred from mutant phenotype
24590174 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

syntaxin-binding protein 1

  • UNC-18 homolog

  • minisatellite 10g detected by probe MMS10

  • protein unc-18 homolog 1

  • protein unc-18 homolog A

  • unc-18-1

  • unc-18A

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-30234A Clemizole hydrochloride Inhibitor 99.99% Yes
HY-30234 Clemizole Inhibitor 98.42% Yes

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-30234S Clemizole-d4 Inhibitor 99.82% Unkown
HY-RS13989 STXBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-30234B Clemizole sulfate Inhibitor / Unkown
HY-RS21950 Stxbp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28467 Stxbp1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stxbp1 NCBI NCBI:6812